部份中文乳清蛋白/双歧杆菌处方资料（仅供参考）
商品名：Lebanon-s
英文名：Lactomin/Bifidobacterium
中文名：乳清蛋白/双歧杆菌复合散
生产商：日本若本制药 レベニンS配合散/レベニンS配合錠
薬效分类名
三菌种配合乳酸菌制剤
批准日期：2015年12月
商標名
LEBENIN-S POWDER
一般名
ラクトミン（Lactomin）（JAN）
菌種
ストレプトコッカス・フェカリス（Streptococcus faecalis）
ラクトバチルス・アシドフィルス（Lactobacillus acidophilus）
性状
它是白色至略带棕褐色的粉末，无异味或无异味
一般名
ビフィズス菌（Bifidobacterium）
菌種
ビフィドバクテリウム・ロンガム（Bifidobacterium longum）
性状
它是白色至略带棕褐色的粉末，无异味或无异味。
处理注意事项
稳定性测试
通过使用Lebenin S复合粉进行的长期储存测试（25±1°C，相对湿度60±5％，3年6个月），可以确定在正常市场分布下它可以稳定3年6个月。
作为使用Lebenin S组合片剂的长期储存测试（25±2°C，相对湿度60±5％，3年）的结果，证实了其在正常的市场分布下可以稳定3年。
药物药理学
1.有机酸生产（体外）
作为检查该药物的乳酸菌的有机酸产生的结果，在每种乳酸菌的单一培养物中，粪便链球菌和嗜酸乳杆菌产生乳酸，长双歧杆菌产生乳酸和乙酸。
2.抑制病原体生长（体外）
含Lebenin S的粉末与三种病原体（肠毒素大肠杆菌，鼠伤寒沙门氏菌，金黄色葡萄球菌）的混合培养显着抑制了每种病原体的生长。
3.生物等效性测试
在一项体外试验中，考虑到饭后胃内pH值的时间进程和通过胃的时间，将Lebenin S组合粉和Lebenin S组合片的细菌存活率与时间进行了比较。 计算活细胞计数平均值之间的差的90％置信区间的结果，证实了生物等效性。
适应症
改善肠道菌群异常引起的各种症状
用法与用量
S组合散
通常，成人每天3至6克，分三剂口服。剂量可以根据年龄和症状进行调整。
S组合片
通常，成人每天分3至6片，分3剂口服。剂量可以根据年龄和症状进行调整。
包装
S组合粉：1公斤（500克x2）（瓶装）
S组合片：120片，600片，1200片（PTP）
制造分销商
若本制药有限公司 注：以上中文处方资料不够完整，使用者以原处方资料为准。
完整说明资料附件： https://www.info.pmda.go.jp/go/pack/2316003B1066_1_02/
LEBENIN-S POWDER（レベニンS散）
Brand name : LEBENIN-S POWDER
Active ingredient: Lactomin
Streptococcus faecalis
Lactobacillus acidophilus
Bifidobacterium
Bifidobacterium longum
Dosage form: white powder
Print on wrapping:
Effects of this medicine
This medicine improves abdominal symptoms such as diarrhea, loose stool, constipation or abdominal bloating by bifidobacteria/lactic acid bacteria normalizing intestinal environment.
It is usually used to improve various symptoms due to abnormalities in the intestinal flora.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions(itch, rash, etc.) to any medicines.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products.(Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines)
Dosing schedule(How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, for adults, take 1 to 2 g at a time, 3 times a day. The dosage may be adjusted according to the disease, age or symptoms. Strictly follow the instructions.
•If you miss a dose, take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should not take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
• Possible adverse reactions to this medicine
No pertinent entries.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets.If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
No pertinent entries.
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children.Store away from direct sunlight, heat and moisture.
•Discard the remainder.Do not store them.
WAKAMOTO PHARMACEUTICAL CO.LTDInternal
Revised: 8/2015
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies(benefits).It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
