部份中文小児用克拉霉素处方资料（仅供参考）
英文名：Clarithromycin
商品名：Clarith
中文名：小児用克拉霉素干糖浆
生产商：大正制药
药品介绍
克拉霉素（Clarithromycin，クラリス）是红霉素的衍生物，上世纪90年代初由日本大正公司开发成功，并以商品名Clarith。本品具有高效、口服易于吸收，对酸稳定性好的特点，该药对革兰阳性菌的活性强，对酶稳定，在血清和肺组织中浓度高。临床证明体内活性是红霉素的6～10倍，是交沙霉素的14～35倍。并以改善生物利用度为特征，组织和细胞内分布极好、半衰期长，其不良反应发生率仅为3%.
クラリス錠50小児用／クラリスドライシロップ10％小児用
药物分类名称
大环内酯类抗生素制剂
批准日期：1991年10月
商標名
Clarith tablets 50 for pediatric
Clarith dry syrup 10% for pediatric
一般的名称
クラリスロマイシン（clarithromycin）
化学名
（2R,3S,4S,5R,6R,8R,10R,11R,12S,13R）-5-（3,4,6-Trideoxy-3-dimethylamino-β-D-xylo-hexopyranosyloxy）-3-（2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyloxy）-11,12-dihydroxy-6-methoxy-2,4,6,8,10,12-hexamethyl-9-oxopentadecan-13-olide
（日局に準拠）
分子式
C38H69NO13
分子量
747.95
性状
它是白色结晶性粉末，带有苦味。 它微溶于丙酮或氯仿，微溶于甲醇，乙醇（95）或乙醚，几乎不溶于水。
化学構造式
融点
220～227℃
略号
CAM
处理注意事项
<干糖浆>
打开铝制枕头包装后，将其存放在远离湿气的阴影区域。
药效药理
作用机理
它与细菌70S核糖体的50S亚基结合并抑制蛋白质合成。
药理作用
抗菌作用
一些革兰氏阴性细菌，例如葡萄球菌，晶状体球菌，肺炎球菌的需氧革兰氏阳性细菌，莫拉克斯拉（Branhamera）catalaris，流行性感冒，区域细菌，百日咳，弯曲杆菌，衣原体，支原体和它对分枝杆菌-AB复合物（MAC）具有抗菌作用，其作用等于或优于其他大环内酯类抗生素（体外）。
人类主要代谢物第14位氢氧化物的抗菌活性
它具有与未修饰形式几乎相同的抗菌活性，但分枝杆菌
它比抗Avium复合物（MAC）的未改变形式（体外）弱。
对动物感染模型的作用
在腹膜内感染，皮下感染和呼吸道感染的小鼠模型中，它反映了该药物的良好组织迁移并显示出优异的效果。
适应症
一般感染
<适用细菌种>
对此药物敏感，葡萄糖属，伦扎属，肺炎，莫拉克斯拉（Branhamera）/加泰罗尼亚，流感，Regionella，百日咳，弯曲杆菌，衣原体，支原体
<适应>
浅表皮肤感染，深层皮肤感染，淋巴/淋巴结炎，慢性脓皮病，继发性感染，例如外伤/烧伤和手术伤口，咽/喉炎，扁桃体炎，急性支气管炎，肺炎，肺脓肿，继发性慢性呼吸道感染，感染性肠炎，中耳炎症，鼻窦炎，红热，百日咳
传播性分枝杆菌-Ab复合体（MAC）与后天免疫机能丧失综合症（AIDS）
<细菌种适应>
阿布分枝杆菌复合物（MAC）对这种药物敏感
<适应>
传播性分枝杆菌-Ab复合体（MAC）与后天免疫机能丧失综合症（AIDS）
用法与用量
1.一般传染病
片剂：
通常情况下，口服单独给予克拉霉素，每10〜15毫克的（效价）的2-3倍的儿童每天重1kg。对于军团菌肺炎，口服单位体重1公斤一个（效价）两次或三次的天以15mg给药。另外，应根据您的年龄和症状增加或减少。
干糖浆：
在使用前悬浮，通常口服给药分为克拉霉素儿童每10〜15毫克的（效价）2-3次，每天1个1kg。
对于军团菌肺炎，口服单位体重1公斤一个（效价）两次或三次的天以15mg给药。
另外，应根据您的年龄和症状增加或减少。
与获得性免疫缺陷综合症（AIDS）（MAC）疾病相关.弥散性鸟分枝杆菌复合
片剂：
通常，儿童在每15毫克（效价）如克拉霉素用于口服给药的两个部分每日体重1千克。
另外，应根据您的年龄和症状增加或减少。
干糖浆：
在使用前悬浮，通常在以每15毫克（效价）如克拉霉素用于口服给药的两个部分每日体重1千克孩子。
另外，应根据您的年龄和症状增加或减少。
包装
片剂[儿童用]
50：
100 PTP片[10片x 10]
PTP 500片[10片x 50]
干糖浆10％[儿童用]
塑料瓶100克（带干燥剂）
分离度0.5g x 120（含干燥剂）
生产与销售
大正制药有限公司
注：以上中文处方资料不够完整，使用者以原处方资料为准。
完整资料附件：
https://www.info.pmda.go.jp/go/pack/6149003F1031_1_35/
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Clarith dry syrup 10% for pediatric（Clarithromycin）
Brand name : Clarith dry syrup 10% for Pediatric Use
　Active ingredient: Clarithromycin
　Dosage form: slightly reddish white powder
　Print on wrapping: T16
Effects of this medicine
This medicine is macrolide antibiotics, inhibits protein synthesis of bacteria to suppress bacterial growth, and shows antibacterial action.
It is usually used in the treatment of wide-range infections such as respiratory infections, otorhinologic infections, skin infections, etc.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have: hepatic disorder, renal disorder, cardiac disease or hypokalemia.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•This medicine is to be suspended before use. In general, for children, take 0.1 to 0.15 g of the dry syrup (10 to 15 mg of the active ingredient [titer]) per kilogram of body weight daily, in two or three divided doses. In the treatment of Legionella's pneumonia, take 0.15 g (15 mg [titer]) per kilogram of body weight daily, in two or three divided doses. In any case, the dosage may be adjusted according to the diseases, age or symptoms. However, in the treatment of common infections, the daily dosage is limited to 4 g (400 mg [titer]). Strictly follow the instructions of your doctor and pharmacist.
•If you miss a dose, take the missed dose as soon as possible when you remember that you missed a dose. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
• Possible adverse reactions to this medicine
The most commonly reported adverse reactions include abdominal pain, diarrhea, rash, hallucination, disorientation (not knowing the place where one is, what time or one's own name is), impaired consciousness, delirium, mania (euphoria, tendency to be excited, become active), tremor (trembling of the limbs), numbness, ear ringing, diminished hearing, olfactory disorder, oral erosion, tooth discoloration, muscular pain, candidiasis (sore and itch due to eczema in the external genitalia, stomatitis, difficulty in swallowing or eating), palpitation and hypoglycemia. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•breathing difficulty, convulsion, systemic redness accompanied by itching  [shock, anaphylaxis]
•palpitation, chest pain, dizziness  [QT prolongation, ventricular tachycardia, ventricular fibrillation]
•general malaise, loss of appetite, yellowing in the skin or conjunctiva  [fulminant hepatitis, hepatic dysfunction, jaundice, hepatic failure]
•general malaise, headache, nasal bleeding, gum bleeding  [thrombocytopenia, pancytopenia, hemolytic anemia, leukocytopenia, agranulocytosis]
•redness in the skin, blister, bulbar conjunctival congestion  [toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiform]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep the medicine out of the reach of children. Store it away from light, heat and moisture.
•Discard the remainder. Do not store them.
Revised: 11/2013
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.