部份中文米格列奈钙/伏格列波糖处方资料（仅供参考）
英文名：Mitiglinide Calcium Hydrate/Voglibose
商标名：GLUBES Combination Tab
中文名：米格列奈钙/伏格列波糖复方片
生产商：橘生制药
药品简介]
2011年7月21日，橘生制药宣布，新药Glubes（Mitiglinide Calcium Hydrate/Voglibose）在日本获批上市。这是一种快速分泌胰岛素促泌剂的固定剂量组合片剂，用于治疗2型糖尿病。
GLUBES®是米格列奈和伏格列波糖的固定剂量组合片剂，前者是Kissei最初开发的一种快速短效胰岛素促分泌剂，后者是餐后高血糖症的改善剂。该药物通过米格列奈诱导餐后快速胰岛素分泌和伏格列波糖延迟餐后碳水化合物消化和吸收的作用，显著改善了餐后高血糖症。 
グルベス配合錠
药用分类名称
速效胰岛素分泌促进剂/餐后过血糖改善剂
批准日期：2011年7月
商標名
GLUBES Combination Tab.
米格列奈水合钙
一般名：ミチグリニドカルシウム水和物（Mitiglinide Calcium Hydrate) (JAN)
化学名：Monocalcium bis{(2S)-2-benzyl-4-[(3aR,7aS)-octahydroisoindol-2-yl]-4-oxobutanoate}dihydrate
分子式：C38H48CaN2O6・2H2O
分子量：704.91
構造式：
性状：
米格列奈水合钙是白色粉末。容易溶于甲醇或乙醇（99.5），不易溶于水。
观察到晶体多态性。
伏格列波糖
一般名：ボグリボース（Voglibose）（JAN）
化学名：3,4-Dideoxy-4-[2-hydroxy-1-(hydroxymethyl)ethylamino]-2-C-(hydroxymethyl)-D-epi-inositol
分子式：C10H21NO7
分子量：267.28
構造式：
性状：
伏格列波糖是白色晶体或结晶粉末。它很容易溶于水，容易溶于醋酸（100），不易溶于甲醇，很难溶于乙醇（99.5）。溶解在0.1mol/L盐酸试液中。
处理注意事项
该制剂在片剂表面可能出现红斑，但由使用的染料。
药效药理
1. 血糖升高抑制作用
（1）针对健康成年男性，通过交叉方法测量血浆葡萄糖浓度，在蔗糖负荷前口服，该制剂和标准制剂施用时的血糖升高抑制作用相等（米格列奈水合钙10mg和伏格列波糖0.2mg的组合给药）。
（2）当口服米格列奈水合钙和伏格列波糖时，在烟酰胺前治疗链霉素诱导2型糖尿病大鼠中，液体饲料口服负荷后的血糖升高被抑制，加载后的血浆葡萄糖浓度-时间曲线下面积值被加法降低（体内）。
2. 作用机制
（1）米格列奈水合钙
1） 通过结合胰腺+细胞的磺酰尿素受体，通过抑制ATP敏感K+通道（KATP通道）电流促进胰岛素分泌（体外）。
（2）伏格列波糖
1） 对猪小肠衍生的麦芽糖酶和蔗糖分别表现出约20倍和30倍的强抑制作用，大鼠小肠衍生的麦芽糖和蔗糖抑制活性分别为阿卡尔博斯的270倍和190倍（体外）。另一方面，对猪和大鼠胰腺β-淀粉酶的抑制作用约为1/3000的阿卡尔博斯，对β-葡萄糖苷酶没有抑制活性（体外）。
2）从大鼠小肠衍生的蔗糖酶 - 抑制对异麦芽糖酶复合物的二糖水解酶的抑制模式是相互竞争的（体外）。
适应症
2型糖尿病
然而，只有当与米格列奈钙和伏格列波糖联合治疗确定合适时，它才会被确定为合适。
用法与用量。
通常，成人每片（10mg/0.2mg作为米格列奈钙和伏格列波糖）在每天三次餐前口服。
包装
配合錠：
100錠(PTP)，210錠(PTP)，500錠(PTP)，1050錠(PTP)

制造供应商
橘生制药工业有限公司
注：以上中文处方资料不够完整，使用者以原处方资料为准。
完整说明附件：
https://www.info.pmda.go.jp/go/pack/3969102F1020_1_08/
グルベス配合錠 GLUBES Combination Tab，米格列奈钙/伏格列波糖复方片（Voglibose+Mitiglinide Calcium Hydrate）
Brand name : GLUBES Combination Tab.
　Active ingredient: Mitiglinide calcium hydrate
 Voglibose
　Dosage form: pale red tablet, major axis: 10.0 mm, minor axis: 5.0 mm, thickness 3.0 mm
　Print on wrapping: グルベス配合錠 糖尿病用薬 MV 食直前に服用 GLUBES
Effects of this medicine
This medicine stimulates insulin secretion, and by blocking the enzyme α-glucosidase that degrades carbohydrates to glucose, delays glucose absorption from the small intestine which enables it to control the elevation of blood-glucose level after meal (postprandial hyperglycemia) and improve glycemic control.
It is usually used to treat type 2 diabetes.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have ever experienced any allergic reaction (itch, rash etc.) to any medicine.
If you are a patient with ketosis, diabetic coma or precoma, type 1 diabetes, infection, hepatic or renal dysfunction, heart disease, undergone a laparotomy, experienced bowel obstruction, Roemheld syndrome, intestinal disorder, pituitary gland malfunction, adrenal gland dysfunction or gastrointestinal disorder.
If you are in pre/postoperative period.
If you are injured, starving, state of malnutrition or debility, or an alcohol consumer.
If you engage in intense muscular exercise.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products.(Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines)
Dosing schedule(How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•General dosage regimen: For adults, take 1 tablet at a time, 3 times a day, just before (within 5 minutes) meals. Strictly follow the instructions of your doctor/pharmacist.
•If you have already started meal, skip the missed dose and continue your regular dosing schedule. DO NOT take double doses to make up for the missed dose.
•If you took too much of the medicine (more than ordered), check with your doctor/pharmacist.
•Do not stop taking the medicine without the instructions of your doctor.
Precautions while taking this medicine
•Strictly adhere to dietary instructions given and to kinesitherapy prescribed.
•The medicine may cause you to have hypoglycemic symptoms such as dizziness or light-headedness. Pay attention when you drive, work at heights, or operate dangerous machinery while taking it.
•If you have hypoglycemic symptoms, take glucose not sucrose or something containing enough glucose such as soft drink.
Possible adverse reactions to this medicine
Common side effects are reported as below.If any of them occurs, check with your doctor/pharmacist: symptoms of hypoglycemia, enlarged feeling of abdomen, numbness, abdominal pain, increased flatus, weight increase, etc.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•pressured feeling or constrictive pain in chest, cold sweat[myocardial infarction]
•dizziness, abnormal craving for food, tremor in limbs[hypoglycemia]
•abdominal distension,meteorism, increased flatus[bowel obstruction]
•general malaise, loss of appetite, yellowing of skin or conjunctiva [fulminant hepatitis, hepatic dysfunction, jaundice]
•constipatin, faint consciousness, jadgment failure[disturbance of consciousness due to exacerbation of heperammonemia in patients with liver cirrhosis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out the reach of children. Store away from direct sunlight heat and moisture.
•Discard the remainder. Do not store them.