部份中文COLY-MYCIN S处方资料（仅供参考）
商品名：COLY-MYCIN S
英文名: NEOMYC/COLIST/HYDROCORT/THONZN
中文名: 多粘菌素注射剂
生产商: JHP PHARMACEUTICALS LLC
药品介绍
多粘菌素E甲磺酸钠 Colistimethate Sodium
中文别名：多粘菌素E甲磺酸钠、肠粘菌素甲磺酸钠、甲磺酸粘菌素、粘菌素甲磺酸钠、粘菌素甲烷磺酸钠
英文别名：Colimicina、Colimycine、Colistimethate、Colistimethatum Natricum、Colistin Sodium Methamesulfonate、Colistin Sulphomethate Sodium、Colistinm、Colistinmethane Sulfonate Sodium、Coly-Mycin、Coly-Mycin M、Methacolimycin、Pentasodium Colitinmethanesulfate
药品类别：其它抗生素类抗感染药
适应症
本品为绿脓杆菌感染的首选药物之一，可治绿脓杆菌性脑膜炎，也可用于败血症、泌尿系统、腹部及其它手术后感染。
用法用量
肌注或皮注：每次100万单位，1日2～4次。或遵医嘱！
注意事项
主要为肾毒性及神经毒性，但比硫酸多粘菌素Ｅ小。有时会出现暂时性的感觉异常、皮肤瘙痒、视觉障碍、语言紊乱、药物热、胃肠道菌群失调等。肾功能不全者慎用。
包装
COLY-MYCIN S OTIC DRP 10ML NEOMYC/COLIST/HYDROCORT/THONZN  ENDO LABORATORIES 63481042105
COLY-MYCIN M 150 MG VL 6X10ML COLISTIN (COLISTIMETHATE NA) JHP PHARMACEUTICALS LLC 42023010706
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Coly-Mycin® S Otic with Neomycin and Hydrocortisone
(colistin sulfate—neomycin sulfate—thonzonium bromide—hydrocortisone acetate) Otic Suspension
DESCRIPTION
Coly-Mycin® S Otic with Neomycin and Hydrocortisone (colistin sulfate with neomycin and hydrocortisone ) (colistin sulfate—neomycin sulfate— thonzonium bromide—hydrocortisone acetate otic suspension) is a sterile antibacterial and antiinflammatory aqueous suspension containing in each mL: Colistin base activity, 3 mg (as the sulfate); Neomycin base activity, 3.3 mg (as the sulfate); Hydrocortisone acetate, 10 mg (1%); Thonzonium bromide, 0.5 mg (0.05%); Polysorbate 80, acetic acid, and sodium acetate in a buffered aqueous vehicle. Thimerosal (mercury derivative), 0.002%, is added as a preservative. It is a nonviscous liquid, buffered at pH 5, for instillation into the canal of the external ear or direct application to the affected aural skin.
The structural formulas of colistin sulfate (mixture of Colistin A & B), neomycin sulfate (mixture of neomycin A, B & C), hydrocortisone acetate ((11β)-21-(acetyloxy)-11,17-dihydroxypregn) methyl]-2 pyrimidinylamino] ethyl]-N,N-dimethyl-1 hexadecanaminium, bromide) are represented below:
Coly-Mycin®S Otic with Neomycin and Hydrocortisone (colistin sulfate—neomycin sulfate—thonzonium bromide—hydrocortisone acetate) Structural Formula Illustration
INDICATIONS
Coly-Mycin® S Otic is indicated for the treatment of superficial bacterial infections of the external auditory canal, caused by organisms susceptible to the action of the antibiotics; and for the treatment of infections of mastoidectomy and fenestration cavities, caused by organisms susceptible to the antibiotics.
DOSAGE AND ADMINISTRATION
Therapy with this product should be limited to 10 days. (See WARNINGS.)
The external auditory canal should be thoroughly cleansed and dried with a sterile cotton applicator.
When using the calibrated dropper:
For adults, 5 drops of the suspension should be instilled into the affected ear 3 or 4 times daily.
For pediatric patients, 4 drops are suggested because of the smaller capacity of the ear canal.
The patient should lie with the affected ear upward and then the drops should be instilled. This position should be maintained for 5 minutes to facilitate penetration of the drops into the ear canal. Repeat, if necessary, for the opposite ear.
If preferred, a cotton wick may be inserted into the canal and then the cotton may be saturated with the suspension. This wick should be kept moist by adding further solution every 4 hours. The wick should be replaced at least once every 24 hours.
HOW SUPPLIED
Coly-Mycin® S Otic is supplied as:
NDC 42023-108-01...........5 mL bottle with dropper
Each mL contains: Colistin sulfate equivalent to 3 mg of colistin base activity, Neomycin sulfate equivalent to 3.3 mg neomycin base activity, Hydrocortisone acetate 10 mg (1%), Thonzonium bromide 0.5 mg (0.05%), and Polysorbate 80 in an aqueous vehicle buffered with acetic acid and sodium acetate. Thimerosal (mercury derivative) 0.002% is added as a preservative.
A sterilized dropper-cap assembly for use on the bottle of suspension is included in the package.
Shake well before using.
Store at 20°–25°C (68°–77°F).
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=256f4083-5b34-4643-a75a-dd1a59a5d964