部分中文氟氯西林处方资料（仅供参考）
【别名】
氟氯苯甲异恶唑青霉素钠;氟氯青;氟氯青霉素钠;氟氯西林;氟沙星 ,奥佛林 ,氟氯苯唑青霉素钠
【外文名】
Flucloxacillin Na,FLUCLOXACILLIN
【成分】
氟氯西林钠
【性状】
为白色或类白色结晶性粉末，易溶于水（１：１），溶于乙醇（１：１２），或丙酮（１：１２）。
【药理作用】
本品有抗耐葡萄球菌所产生的β－内酰胺酶能力。肌注同量的本品与氯唑西林，本品的血药浓度明显较高，血中有效浓度维持时间较长。
【适应症】
主要用于治疗耐青霉素金黄色葡萄球菌的严重感染，以及呼吸道感染（如急性咽炎、化脓性扁桃体炎）、治疗感冒继发细菌感染、急慢性气管炎、支气管炎、肺炎、肺脓肿、脓胸、骨髓炎、化脓性关节炎、急慢性中耳炎、鼻副窦炎、牙周炎、疖、痈、丹毒、蜂窝组织炎、破伤风、甲沟炎、创面及伤口感染、烧伤感染、导尿后引起的尿道炎、前列腺炎、淋病、心内膜炎、革兰阳性菌尤是金黄色葡萄球菌引起的败血症。
【用量用法】
静滴、静注：２～４ｇ／日，分２～４次注射。溶于２０ｍｌ注射用水中，在３～４分钟内缓注或加入输液中静滴。胸腔内注射：２５０ｍｇ／日，溶于５～１０ｍｌ注射用水中。关节腔注射：２５０～５００ｍｇ／日，溶于５ｍｌ注射用水中。口服：０．２５～０．５ｇ／次，４～６次／日，饭前２小时服。儿童：２～１０岁为成人剂量的一半，＜２岁为成人剂量的１／４。
【注意事项】
偶有过敏反应（如皮疹）、恶心、呕吐、上腹不适、结肠炎等。长期应用应检查肝功能。在怀疑复合感染时，可合用阿莫西林、氨芐西林、头孢三嗪、头孢他啶等治疗。用前需做皮试。
【类别】
抗生素
PATIENT INFORMATION LEAFLET
FLUCLOXACILLIN 125MG/5ML SUGAR-FREE POWDER FOR ORAL SOLUTION
FLUCLOXACILLIN 250MG/5ML SUGAR-FREE POWDER FOR ORAL SOLUTION
Read all of this leaflet carefully before you start taking your medicine. Keep this leaflet. You may need to read it again. If you have further questions, please ask your doctor or pharmacist (chemist). This medicine has been prescribed for you personally and you should not pass it on to others. It may harm them, even if their symptoms are the same as yours.
WHAT IS IN THIS LEAFLET?
This leaflet answers some common questions about your medicine. It contains the following information:
1 What your medicine is and what it is used for
2 Before you take your medicine
3 How to take your medicine
4 Possible side effects of your medicine
5 How to store your medicine
6 Further information
1 What your medicine is and what it is used for
Flucloxacillin is an antibiotic used to treat infections by killing the bacteria that can cause them. It belongs to a group of antibiotics called “penicillins”.
Flucloxacillin is used to treat:
•chest infections
•ear infections
•heart infections
•meningitis
•blood infections
•kidney, bladder or urethra (the tube which carries urine from the bladder) infections.
•throat or nose infections
•skin and soft tissue infections
•bone and joint infections
•digestive system infections
Flucloxacillin can also be used to prevent infections during major surgery, particularly heart or orthopaedic surgery.
2 Before you take your medicine
Do not take this medicine if:
•You have ever had an allergic reaction to flucloxacillin or any other penicillin antibiotics (see symptoms section 4)
•You have ever had an allergic reaction to any of the other ingredients of this medicine – see list of ingredients in section 6, Further Information
•You suffer from liver problems, as this medicine could cause them to worsen.
Check with your doctor or pharmacist before taking this medicine if:
•You suffer from kidney problems, as you may require a lower dose than normal
•You suffer from liver problems, as this medicine could cause them to worsen
•You are 50 years of age or older
•You have other serious illnesses (apart from the infection this medicine is treating).
Check with your doctor or pharmacist before taking this medicine if you are taking any other medicines, especially:
•Probenecid or sulfinpyrazone (used to treat gout)
•Methotrexate (a chemotherapy drug)
•The contraceptive pill as antibiotics can make these less effective (you will need to use extra precautions such as condoms while taking flucloxacillin and for a full 7 days after you finish taking it)
•Oral typhoid vaccine (antibiotics can make this less effective)
•Sugammadex (used with general anaesthetics)
•Piperacillin (an antibiotic taken by injection).
Some medicines may affect the way others work. Always tell your doctor about all the medicines you are taking. This means medicines you have bought yourself as well as medicines on prescription from a doctor.
Pregnancy and breastfeeding
If you are pregnant, planning to become pregnant or are breastfeeding ask your doctor or pharmacist for advice before taking this medicine.
Tests
Regular monitoring of liver and kidney function should be performed whilst taking flucloxacillin for a long period of time. Tell your doctor that you are taking Flucloxacillin if you are having urine tests or blood tests because it may affect the results.
Important information about some of the ingredients in your medicine:
This medicinal product contains sorbitol. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.
The 125mg/5ml solution contains 17.08mg sodium per 5ml dose, and the 250mg/5ml solution contains 49.41mg sodium per 5ml dose. To be taken into consideration by patients on a controlled sodium diet.
3 How to take your medicine
Follow all directions given to you by your doctor or pharmacist. Their directions may differ from the information contained in this leaflet. The pharmacist’s label should tell you how much to take and how often. If it does not, or you are not sure, check with your doctor or pharmacist.
How much of your medicine to take and when to take it:
The dose will depend on the patient and will be decided by your doctor. However, the usual doses for each age group are -
Flucloxacillin Sugar Free Oral Solution 125mg/5ml
Adults (including the elderly): 10ml four times a day
(5ml is equivalent to one teaspoonful)
Children (2 - 10 years of age): 5ml four times a day
Children under 2 years of age: 2.5ml four times a day
Flucloxacillin Sugar Free Oral Solution 250mg/5ml
Adults (including the elderly): 5ml four times a day
(5ml is equivalent to one teaspoonful)
Children (2-10 years of age): 2.5ml four times a day
Children under 2 years of age: 1.25ml four times a day
INSTRUCTIONS FOR RECONSTITUTION OF THE POWDER
1. Remove the cap and add the correct volume of potable water (87mls if you have been given the 125mg/5ml strength of product and 79mls if you have been given the 250mg/5ml strength of product)
2. Replace the cap and shake well.
3. Remove the cap once more and place the adaptor (Fig 1) into the bottle opening. The adaptor should not be removed at any stage.
4. Replace the cap, do not shake any further.
INSTRUCTIONS FOR USE OF THE SYRINGE
1. Remove the cap and if necessary push the adaptor into the neck of the bottle (Fig 1).
2. Push the plunger of the syringe to remove all the air.
3. Insert the syringe into the adaptor until it is firmly in place (Fig 2).
4. Whilst holding the bottle and syringe shake the contents well.
5. While holding the bottle, turn the entire assembly upside down.
6. Whilst supporting the syringe draw off the required amount of medicine into the syringe (Fig 3).
7. Turn the assembly back up the right way and remove the syringe from the bottle.
8. Replace the cap onto the bottle.
Administer the dose by introducing the tip of the syringe into the mouth of the infant/child, then apply a light pressure on the plunger to slowly release the solution. Keep it out of the reach of children.
Note: For subsequent dosage follow steps 3 and 4 above, before shaking in order to prevent leakage.
When to take your medicine:
Take your medicine on an empty stomach, at least thirty minutes to one hour before meals/food. It is important that you take your medicine at the right times.
How long to take your medicine for:
Keep taking your medicine until your doctor tells you to stop. Do not stop taking it just because you feel better. If you stop taking the medicine, your infection may return or get worse. If you are still unwell after taking all the medicine, go and see your doctor.
If you take more of your medicine than you should:
If you (or somebody else) takes too much of your medicine, talk to your doctor or pharmacist immediately.
If you forget to take your medicine:
If you forget to take a dose, take it as soon as you remember, then carry on as before. Do not take a double dose to make up for the dose you have missed.
4 Possible side effects of your medicine
Like all medicines, Flucloxacillin Sugar Free Oral Solution may cause unwanted side-effects. If they occur, they are likely to be temporary, and not serious. However, some may be serious and need medical attention.
STOP taking flucloxacillin and contact your doctor if you experience:
•allergy or hypersensitivity including itchy rash, itching, sore mouth or eyes, swelling of the face, lips, throat or tongue or breathing problems
•severe, bloody diarrhoea
•jaundice (yellow colour in the skin and whites of the eyes)
•severe skin rash with flushing, fever, blisters or ulcers (Stevens Johnson syndrome) or a severe rash with reddening, peeling and swelling of the skin that looks like a burn (toxic epidermal necrolysis).
Tell your doctor if you notice any of the following effects:
•Common (occurs in more than 1 in 100 and less than 1 in 10 users):
Diarrhoea, stomach upset and feeling sick
•Should be mild and wear off after a few days
If severe or lasting longer, tell your doctor
•Very rare (occurs in less than 1 in 10,000 users): Inflammation of the kidney or liver, changes in the numbers of blood cells, (might cause bleeding, easy bruising or skin discolouration), anaemia, skin rash with circular red patches, (Erythema Multiforme). Joint or muscle pains or fever (may develop 2 days after starting treatment)
•Some of these reactions to flucloxacillin can be delayed for up to 2 months after finishing the treatment.
Check with your doctor if you have any problems while taking this medicine, even if you think the problems are not connected with the medicine, or are not listed in this leaflet.
5 How to store your medicine
Do not store above 25°C.
Once reconstituted (mixed) by the pharmacist, store the solution at 2°C to 8°C in a refrigerator and use within 7 days.
Keep this medicine in a safe place where children cannot see or reach it.
Do not use this medicine after the expiry date shown on the label.
Return any left-over medicine to the pharmacist.