噻康唑Tioconazole 
中文别名：噻康唑、的康唑、替可那唑、噻苯乙咪唑
英文别名：Fungibacid、Trosyd、Trosyl
药品类别：抗真菌类 
药理药动
本品为咪唑类广谱抗真菌药。在体外试验中，本品能抑制各种酵母菌及其他真菌的生长，同时对某些革兰阳性菌、阴道嗜血杆菌及阴道毛滴虫也有抑制作用。在体内本品对实验性发癣菌属及阴道念珠菌属感染见效快，真菌转阴率与克霉唑相近。
药动学
本药氢-3标记的1％霜剂20mg涂敷于大鼠的正常皮肤及损伤皮肤24h，前者在24h后血药浓度显示峰值且数值极低，而后者虽吸收迅速，但血药浓度仍低。每日1次，反复用药12日，给药4日后血药浓度达坪值，停药后渐减，未见蓄积作用。向体内的移行量，健康皮肤24h后达16.1％，损伤皮肤达36.7％，提示在角质层中有潴留。本品在体内大多经代谢后排泄。
适应症
主要用于阴道真菌感染，如白色念珠菌、其他念珠菌属及阴道毛滴虫引起的感染。
用法用量
阴道内给药。栓剂，每晚睡前用所附投药器给药1次，每次100mg，连用3日、6日或14日即可奏效。软膏，利用附设的投药器1次用于阴道内，若1次单剂量尚未痊愈，则于1周后再用1次。霜剂，于晚上就寝前外用1次，连用3日。
本品的各种剂型不要在月经期使用。出现过敏症状时应停药。
[剂型与规格]
栓剂：100mg/片。
软膏：6.5％(一剂含本品300mg)。
霜剂：2％(一剂相当本品100mg)。
不良反应
有时会出现局部刺激感、瘙痒、发红、浮肿、丘疹、小水泡、鳞屑、龟裂等皮肤症状。
禁忌症
禁用于对咪唑类抗真菌药有过敏史的患者。孕妇应避免使用本品。不用于角膜、结膜。
MONISTAT 6.5% OINTMENT
Important note
HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you.
This information is not individual medical advice and does not substitute for the advice of your health care professional.
Always ask your health care professional for complete information about this product and your specific health needs.
Monograph title
TIOCONAZOLE - VAGINAL
Phonetic pronunciation(tie-oh-CON-uh-zole)
Common brand name(s)
Vagistat-1
Uses
This medication is used to treat vaginal yeast infections.
Tioconazole ointment reduces vaginal burning, itching, and discharge that may occur with this condition.
This medication is an azole antifungal.
It works by stopping the growth of yeast (fungus) that causes the infection.Ask your doctor before using this medication for self-treatment if this is your first vaginal infection.
This medication only works for vaginal fungal infections. You may have a different type of infection (such as bacterial vaginosis) and may need a different medication.If you have fever, chills, flu-like symptoms, stomach/abdominal pain, or a bad-smelling vaginal discharge, do not use this medication. Contact your doctor immediately because these may be signs of a more serious infection.
How to use
If you are using the over-the-counter product to self-treat, read all directions on the product package before using this medication.
If you have any questions, consult your pharmacist. If your doctor
has prescribed this medication, use it as directed.This product is for vaginal use only. Wash your hands before and after use.
Avoid contact of this ointment with your eyes.
If it gets into your eyes, wash them immediately with plenty of water.
Call your doctor if eye irritation persists.Dosage is based on your medical condition and response to treatment.This product is usually given as a single dose at bedtime or as directed by your doctor. Learn all preparation and usage instructions in the product package. Lie on your back with your knees toward your chest. Insert the applicator filled with medication into the vagina as far as it will comfortably go. Slowly press the plunger of the applicator in to apply the full dose of the ointment.
If you have itching/burning around the outside of the vagina (vulva), you may also apply some ointment to that area.Do not use tampons, douches, spermicides, or other vaginal products while using this medication. Unscented sanitary napkins may be used for your menstrual period or to protect your clothing from leakage of the medication.Tell your doctor if your condition does not improve after 3 days or lasts more than 7 days. Tell your doctor if your infection returns within 2 months. You may need a different or additional medication to treat your condition.Missed doseNot applicable.
Precautions
See also Uses section.Before using this medication, tell your doctor or pharmacist if you are allergic to it; or to other azole antifungal agents (such as clotrimazole, fluconazole); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.
Talk to your pharmacist for more details.If you have any of the following health problems, consult your doctor or pharmacist before using this medication: diabetes, immune system problems (such as HIV-AIDs), frequent vaginal yeast infections (more than 3 in 6 months or 4 in 1 year).Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Ask your doctor whether you can have sexual intercourse while using this product.
This product may weaken rubber products (such as latex condoms, diaphragms, cervical caps) and lead to failure.
This can result in pregnancy. Therefore, do not use these products during treatment with this medication and for 3 days after treatment is over. Consult your doctor about other forms of barrier protection/birth control(such as polyurethane condoms) during this time.Do not use this medication for self-treatment if you are pregnant.
During pregnancy, this medication should be used only when clearly needed.
If you are pregnant, follow your doctor's instructions on how to use the applicator to insert this medication. Discuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.
Side effects
Headache or vaginal/urethral burning/itching/pain may occur.
If any of these effects persist or worsen, tell your doctor or pharmacist promptly.If your doctor has prescribed this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not
have serious side effects.A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at
1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Drug interactions
The effects of some drugs can change if you take other drugs or herbal products at the same time.
This can increase your risk for serious side effects or may cause your medications not to work correctly.
These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.Some products that may increase the risk of vaginal yeast infections include antibiotics, corticosteroids (such as prednisone), and drugs that suppress the immune system (such as cyclosporine, methotrexate).Keep a list of all the products you use.
Share the list with your doctor and pharmacist to reduce your risk for serious medication problems.
Overdose
This medicine may be harmful if swallowed. If swallowing or overdose is suspected, contact a poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center.
Notes
To help prevent vaginal yeast infections, dry the genital area thoroughly after showering, bathing, or swimming. Avoid wearing tight jeans, nylon underwear, pantyhose, a wet bathing suit, or damp/sweaty exercise clothes for long periods. Wear cotton underwear, and change your underwear daily.If your sexual partner experiences symptoms, they should contact their doctor immediately.
Storage
Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
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