部份中文亚胺培南/西司他丁钠处方资料（仅供参考）
商品名：TIENAM 500MG(抗生素)
英文名：Imipenem 500mg, Cilastatin 500mg
中文名：亚胺培南/西司他丁钠
治疗类别名称
碳青霉烯类抗生素配方
藥理類別：imipenem and enzyme inhibitor
孕婦用藥分級
C 級：
在對照的動物研究試驗中顯示該藥學物對胚胎有不良反應（致畸胎性或殺胚胎性或其他），但未進行人體懷孕婦女研究；或者尚無對照的人體懷孕婦女或動物研究試驗。只有在可能的利益大於潛在的危險，才可使用此藥物。
結構式 
Imipenem：(5R,6S)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Cilastatin：(Z)-7-[(2S)-2-amino-3-hydroxy-3-oxopropyl]sulfanyl-2-{[(1S)-2,2-dimethylcyclopropanecarbonyl]amino}hept-2-enoic acid
UpToDate UpToDate 連結 
藥理作用 
TIENAM為強效之細菌細胞壁合成抑制劑，可有效地殺死(bactericidal)大多數之病源菌-格蘭氏陽性菌，格蘭氏陰性菌，嗜氧菌及厭氧菌。 
適應症 
對IMIPENEM具有感受性革蘭氏陰性菌、陽性菌感染症。 
用法用量 
Tienam之建議劑量係以所需之Imipenem量表示，其中含有等量之Cilastatin。
Tienam之每日總劑量及給藥途徑，需視其感染之種類及嚴重程度而定；其給藥間隔則視其病原菌感受性、腎功能及體重而定。常用劑量：
1. 輕度感染:每8小時一次,每次250mg。
2. 中度感染:每8小時一次,每次500mg。
3. 嚴重度感染:每8小時一次,每次500～1000mg。
副作用 
偶有噁心、胃部不適、食慾不振、口渴、胸悶症狀，或BUN(血中尿蛋白)或 S-GOT，S-GPT，ALP，上昇的可能。
交互作用 
Cyclosporine
CNS side effects (eg, myoclonia, seizures) may be increased.
Ganciclovir
Generalized seizures may occur; avoid use.
Probenecid
Minimal increases in imipenem levels and half-life; do not give probenecid concurrently.
Incompatibility
Do not physically mix imipenem-cilastatin with other antibiotics.
禁忌 
Tienam禁用於對該品任何成份過敏的病人。 
給付規定 
10.5.1.Imipenem + cilastatin（如Tienam）：(87/11/1、93/2/1、93/5/1、99/5/1)
1.經細菌培養證實有意義之致病菌且對其他抗微生物製劑均具抗藥性，而對carbapenem具有 感受性 (sensitivity)。
2.經細菌培養，發現有意義之致病菌對carbapenem及其他抗微生物製劑具有感受性，但病患 對其他抗微生物製劑過敏無其他藥物可供選用時。
3.臨床上為嚴重之細菌感染，且經其他廣效性的非第一線抗微生物製劑治療仍無法控制病情
者。
4.經感染症專科醫師會診，確認有感染症需使用者 (申報費用時需檢附會診紀錄及相關之病 歷資料)。(93/5/1)
注意事項 
1.對β-Lactam (如Penicillins、Cephalosporins或Carbapenems)有過敏病史的患者，應小心使用。
2.患有中樞神經系統感染之孩童使用本藥後會有發生癲癇的危險，因此這類病患禁止使用本製劑。
3.Tienam不可以含乳酸鹽(Lactate)之稀釋液來調配。
4.配製後之溶液可置於室溫4小時，在冰箱中可保存24小時。
5.Tienam不可與其他種抗生素混合。
6.小兒及腎功能不健全的患者其劑量，請參閱藥品內頁說明書。
藥品保存方式 
藥品應置於攝氏15 ~ 25度乾燥處所；如發生變質或過期，不可再使用。 
PRIMAXIN®
Imipenem/Cilastatin sodium
What PRIMAXIN is used for
PRIMAXIN is an antibiotic which is used to treat serious infections caused by bacteria (germs). These infections may occur in many different parts of the body.
PRIMAXIN is sometimes given in addition to other antibiotics.
PRIMAXIN works by killing the bacteria causing the infection.
Before you are given PRIMAXIN
When you must not be given it
Do not use PRIMAXIN if you have an allergy to PRIMAXIN or any of the ingredients listed at the end of this leaflet
Before you are given it
Tell your doctor if:
1. you are pregnant or are breast-feeding
Your doctor will discuss the possible risks and benefits of using PRIMAXIN during pregnancy and breast-feeding. PRIMAXIN passes into breast milk and may be passed on to the baby.
2. you have any medical conditions, especially the following:
a history of seizures or fits
brain disease
kidney disease
bowel problems
3. you have any allergies to other antibiotics, in particular, penicillins and cephalosporins
If you are allergic to any of these, you may be allergic to PRIMAXIN.
4. if you have any allergies to any other medicines or any other substances, such as foods, preservatives or dyes.
If you have not told your doctor about any of the above, tell them before you are given PRIMAXIN.
Taking other medicines
Tell your doctor if you are taking any other medicines, including medicines that you buy without a prescription from your pharmacy, supermarket or health food shop.
Some medicines may affect the way other medicines work. Your doctor or pharmacist will be able to tell you what to do when being given PRIMAXIN with other medicines.
How PRIMAXIN is given
PRIMAXIN is given as a slow injection into a vein. PRIMAXIN must only be given by a doctor or nurse.
Your doctor will decide what dose of PRIMAXIN you will receive, depending on your infection and other factors, such as your weight
PRIMAXIN is usually given in divided doses throughout the day.
While you are using PRIMAXIN
Things you must do
If you feel sick while you are receiving PRIMAXIN, tell your doctor, pharmacist or nurse.
Your doctor may need to slow down the rate of the injection.
If you develop severe diarrhoea, even if it occurs several weeks after PRIMAXIN has been stopped, tell you doctor, pharmacist or nurse.
Diarrhoea may mean that you have a serious condition affecting your bowel. You may need urgent medical care.
Do not take any diarrhoea medicine without first checking with your doctor.
If you have a history of seizures and you are taking anticonvulsant medicines, tell your doctor.
You should continue taking these medicines unless your doctor tells you otherwise. Some patients may develop tremors or seizures while receiving PRIMAXIN.
Things to be careful of Be careful driving or operating machinery until you know how PRIMAXIN affects you.
PRIMAXIN generally does not cause any problems with your ability to drive a car or operate machinery. However, it may cause dizziness or lightheadedness in some people. Make sure you know how you react to PRIMAXIN before you drive a car or operating machinery.
Side Effects
Tell your doctor, nurse, or pharmacist as soon as possible if you do not feel well while you are being given PRIMAXIN.
PRIMAXIN helps most people with infection, but it may have unwanted side-effects in a few people. All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects. PRIMAXIN generally does not cause any problems.
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor or nurse if you notice any of the following and they worry you:
pain, swelling or red skin where you had the injection nausea, vomiting diarrhoea
These are the more common side effects of PRIMAXIN.
Tell your doctor or nurse immediately if you notice any of the following:
high temperature, also called fever seizures or fits tremors, confusion abnormal movements agitation tingling or numbness of the hands and feet fast or irregular heart beat, also called palpitations passing little or no urine (water)
bruising more easily than normal signs of frequent or worrying infections such as fever, severe chills, sore throat or mouth ulcers signs of anaemia, such as tiredness, being short of breath, and looking pale yellowing of the skin and eyes, also called jaundice skin problems such as rash or itchiness red or purplish-red patches on the skin hearing loss severe abdominal or stomach cramps watery and severe diarrhoea, which may also be bloody These are serious side effects of PRIMAXIN.
You may need urgent medical attention. Serious side effects are rare.
A few people may be allergic to some medicines. Tell your doctor or nurse immediately if you notice any of the following:
dizziness, lightheadedness, fainting swelling of the face, lips, mouth or throat which may cause difficulty in swallowing or breathing shortness of breath itchy skin rash pinkish, itchy swellings on the skin, also called hives or nettlerash
If you have these, you may have had a serious allergic reaction to PRIMAXIN.
You may need urgent medical attention.
Also, tell your doctor if you notice:
staining of the teeth and/or tongue a change in the colour of your urine These are other side effects that have been reported with PRIMAXIN Other side effects not listed above may also occur in some patients. Tell your doctor if you notice anything else that is making you feel unwell.
Do not be alarmed by this list of possible side effects. You may not experience any of them.
After PRIMAXIN has been stopped
Things you must do
Tell your doctor immediately if you notice any of the following side effects particularly if they occur several weeks after stopping treatment with PRIMAXIN:
severe abdominal cramps or stomach cramps watery and severe diarrhoea, which may also be bloody fever These are all serious side effects. You may have a serious condition affecting your bowel. You may need urgent medical attention. Do not take any diarrhoea medicine without first checking with your doctor.
Storage
PRIMAXIN will be stored in the pharmacy or on the ward.
The powder for injection is kept in a cool dry place where the temperature stays below 25°C.
Do not use PRIMAXIN if the expiry date (EXP) printed on the carton has passed.
Product Description
Ingredients
Active ingredients:
PRIMAXIN 250 - imipenem 250 mg and cilastatin 250 mg (as the sodium salt) per vial
Inactive ingredients:
sodium bicarbonate
http://www.medicineonline.com/drugs/p/3051/PRIMAXIN%C2%A0I-M-IMIPENEM-AND-CILASTATIN-FOR-INJECTABLE-SUSPENSION.html