部份中文阿莫西林处方资料（仅供参考）
阿莫西林胶囊，阿莫西林口服混悬剂，阿莫西林片剂（咀嚼片）口服使用
美国初始批准：1974
目前的主要变化
适应症和用法，淋病 9/2015
剂量和给药方法，淋病 9/2015
作用机理
阿莫西林是一种抗菌药[见微生物学]。
适应症和用法
阿莫西林是青霉素类抗菌指示的感染治疗药物，由于指定微生物的敏感菌株。
•耳，鼻，喉，泌尿生殖道，皮肤和皮肤结构，和下呼吸道感染。
•在组合H.治疗幽门螺旋杆菌感染和十二指肠溃疡病。
降低耐药细菌的发展和维护阿莫西林胶囊，阿莫西林用于口服悬浮液，阿莫西林片剂（咀嚼）和 - 其它抗菌药物，阿莫西林胶囊，阿莫西林用于口服悬浮液中，阿莫西林片剂（咀嚼）的效力不宜仅用于治疗被证明感染或有这强烈怀疑是由细菌引起的。
用法用量
•在成人中，750至1750毫克/天以分开剂量每8至12小时。在儿科患者> 3个月的年龄为20至45毫克/公斤/天以分开剂量每8至12小时。请参考具体的给药方案的完整处方信息。
•对于新生儿和婴幼儿≤3个月上的剂量为30毫克/公斤/天，每12小时分割。
•每日两次鉴于所有（每12小时），14天1克阿莫西林，克拉霉素500毫克，和30mg兰索拉唑：加药幽门螺杆菌感染：三联疗法。双重疗法：1克阿莫西林和30mg兰索拉唑内容，每14天每日给予三次（每8小时）。
•减少患者严重肾功能损害（GFR <30毫升/分钟）的剂量。
剂型和规格
•胶囊：250毫克，500毫克
•粉口服混悬液125毫克/毫升5和250毫克/毫升5
•片剂（咀嚼）125毫克，250毫克
禁忌症
•一个严重的过敏反应的历史（例如，过敏性反应或Stevens-Johnson综合征）到阿莫西林或β-内酰胺 - 其它（例如青霉素或头孢菌素）
警告和注意事项
•过敏反应：严重的，有时致命的过敏反应具备的，在患者被青霉素治疗的报道。严重过敏反应需要与扶持措施立即紧急处理。
•艰难梭菌相关性腹泻（从轻度腹泻致命性结肠炎）：评估如有腹泻发生。
不良反应
点评最常见的不良反应观察阿莫西林胶囊，片剂（咀嚼片）或口服悬液腹泻，皮疹，呕吐，恶心的临床试验（> 1％）。
药物相互作用
•丙磺舒降低阿莫西林魁的肾小管分泌，可能导致阿莫西林增加的血液水平。
•同时使用阿莫西林和口服抗凝血剂可能会增加凝血酶原时间延长。
•合用别嘌醇增加皮疹的风险。
•阿莫西林可能会降低口服避孕药的疗效。
特殊人群中使用
•儿科：修改在患者12周年轻（≤3个月）的剂量。
About amoxicillin
Type of medicine A penicillin antibiotic
Used for Infections (in adults and children)
Also called Amoxil®
Available as Capsules, oral liquid medicine, sachets and injection
Amoxicillin is given to treat a bacterial infection. It is mainly prescribed for sinus and chest infections, urine infections, ear infections, and some dental infections. You may also be prescribed it to prevent an infection from occurring if you are at particular risk of getting an infection. Amoxicillin is a penicillin antibiotic which treats infection by killing the germs (bacteria) responsible for the infection.
Amoxicillin is sometimes used to get rid of Helicobacter pylori. This is an infection often found in people with stomach ulcers. If you are prescribed it for this reason, you will also be prescribed other medicines to take alongside it.
Before taking amoxicillin
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking amoxicillin it is important that your doctor knows:
•If you suspect you may have glandular fever (the symptoms are high temperature (fever), sore throat, swollen glands).
•If you have an allergic condition, or if you have ever had an allergic reaction to a medicine. This is especially important if you have ever had a bad reaction to any penicillin antibiotic.
•If you have any problems with the way your kidneys work.
•If you are pregnant or breast-feeding. Amoxicillin is not known to be harmful to babies; however, it is still important that you tell your doctor if you are expecting or breast-feeding a baby.
•If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
How to take amoxicillin
•Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about amoxicillin and will provide you with a full list of the side-effects which you may experience from taking it.
•Take amoxicillin exactly as your doctor tells you to. It is usually taken three times daily, every eight hours. Your dose will be different to this if you are being treated with sachets of amoxicillin powder, or if you are being treated for a stomach ulcer. Your doctor or pharmacist will tell you how you should take the medication, and this information will be printed on the label of the pack to remind you. It is important that you space out the doses evenly during the day.
•If you have been given liquid medicine for a child, read the directions carefully to make sure you measure out the correct amount of medicine.
•You can take amoxicillin either with or without food. The capsules should be swallowed with a drink of water.
•If you have been supplied amoxicillin oral powder sachets, stir the powder from the sachet into 10-20 ml of water. Drink the solution as soon as possible after mixing it.
•If you forget to take a dose at the correct time, take one as soon as you remember. Try to take the correct number of doses each day, leaving at least four hours between doses. Do not take two doses at the same time to make up for a forgotten dose.
Getting the most from your treatment
•If you (or your child) have been prescribed the oral liquid medicine, you may find that it causes some staining of the teeth. Brushing the teeth regularly helps to prevent this. Any staining usually disappears soon after the course of antibiotics is finished.
•Even if you feel your infection has cleared up, keep taking the antibiotic until the course is finished (unless a doctor tells you to stop). This is to prevent the infection from coming back.
•Antibiotics are prescribed in short courses of treatment. Your doctor will tell you how long your course of treatment will last - this is not usually for longer than 14 days. If you still feel unwell after finishing the course, go back to see your doctor.
•Some people develop redness and itching in the mouth or vagina (thrush) after taking a course of antibiotics. If this happens to you, speak with your doctor or pharmacist for advice.
•If you are taking the contraceptive 'pill' at the same time as this antibiotic, the effectiveness of the 'pill' can be reduced if you have a bout of being sick (vomiting) or diarrhoea which lasts for more than 24 hours. If this should happen, ask your doctor or pharmacist for advice about what additional contraceptive precautions to use over the following few days. There is no need to use additional precautions for any bouts of sickness or diarrhoea which last for less than 24 hours.
•Amoxicillin can stop the oral typhoid vaccine from working. If you are due to have any vaccinations, make sure the person treating you knows that you are taking this antibiotic.
Can amoxicillin cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with amoxicillin. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common amoxicillin side-effects (these affect less than 1 in 10 people) What can I do if I experience this?
Feeling or being sick Stick to simple foods. Try taking your doses of amoxicillin with something to eat if you are not already doing so
Diarrhoea Drink plenty of water to replace any lost fluids. If the diarrhoea continues, becomes severe, or contains blood, let your doctor know straightaway
Redness and itching in the mouth or vagina (thrush) Speak with your doctor for advice about treatment
Skin rash Let your doctor know as soon as possible as your treatment will need to be changed
Important: if you develop an itchy rash, swollen face or mouth, or have difficulty breathing, these may be signs that you are allergic to a penicillin antibiotic. Do not take any more amoxicillin and speak with your doctor or go to your local accident and emergency department straightaway.
If you experience any other symptoms which you think may be due to the antibiotic, speak with your doctor or pharmacist for further advice.
How to store amoxicillin
•Keep all medicines out of the reach and sight of children.
•Store in a cool, dry place, away from direct heat and light.
•If you have been given liquid medicine, this will have been made up by the pharmacy and lasts for 14 days. Make sure you check the expiry date on the bottle and do not use it after this date.
Important information about all medicines
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
If you buy any medicines, check with a pharmacist that they are safe to take with your other medicines.
If you are having an operation or any dental treatment, tell the person carrying out the treatment which medicines you are taking.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
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Further reading & references
•Manufacturer's PIL, Amoxil® Paediatric Suspension; GlaxoSmithKline UK, The electronic Medicines Compendium. Dated September 2015.
•Manufacturer's PIL, Amoxil® Capsules 250/500 mg; GlaxoSmithKline UK, The electronic Medicines Compendium. Dated September 2015.
•Manufacturer's PIL, Amoxil® Sachets 3g Sucrose-Free; GlaxoSmithKline UK, The electronic Medicines Compendium. Dated September 2015.
•British National Formulary; 70th Edition (Sep 2015) British Medical Association and Royal Pharmaceutical Society of Great Britain, London
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4c0f348a-a65d-409c-8668-207c82a5e3cb