部份中文盐酸西替利嗪处方资料（仅供参考）
英文名：Cetirizine Hydrochloride
商品名：Zyrtec Dry Syrup
中文名：盐酸西替利嗪干糖浆
生产商：第一三共制药
药品简介
Zyrtec（Cetirizine Hydrochloride，盐酸西替利嗪）是一种选择性组胺H1受体拮抗制剂。主要用于缓解变态反应性疾病的过敏症状，临床上用于治疗变应性鼻炎、荨麻疹、血管神经性水肿等皮肤粘膜过敏性疾病，也用于减轻感冒时的过敏症状。
ジルテックドライシロップ1.25%
治疗类别名称
长效选择性H1受体拮抗剂/过敏性疾病治疗剂
批准日期：2006年7月
商品名
Zyrtec Dry Syrup
一般的名称
セチリジン塩酸塩（Cetirizine Hydrochloride）
化学名
2-(2-{4-[(RS)-(4-Chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid dihydrochloride
分子式
C21H25ClN2O3・2HCl
分子量
461.81
性状
它是一种白色结晶粉末。极易溶于水，微溶于乙醇(99.5)。 溶于0.1mol/L盐酸试液。水溶液(1→10)不显示旋光性。
化学構造式
融点
204～210℃（分解）
分配係数
24.3（pH7、水-オクタノール系）
药效药理
作用机制
它通过选择性结合组胺H1受体来抑制组胺的作用。
组胺H1受体拮抗作用
它以剂量依赖性方式抑制离体器官（人支气管平滑肌）中的组胺反应。此外，它还抑制了组胺引起的皮肤反应和组胺引起的鼻部症状，并且效果迅速而持久（人类）。
它对组胺H2、多巴胺、乙酰胆碱和血清素受体（大鼠、豚鼠）的亲和力低，对中枢神经系统中的组胺H1受体（大鼠）影响较小。
对嗜酸性粒细胞的作用
它在体外和体内抑制嗜酸性粒细胞的迁移，并抑制超氧化物的产生，这是嗜酸性粒细胞活化的指标（人类）。
介质释放抑制作用
它抑制人肺切片中白三烯和前列腺素D2的释放。
适应症
〔成人〕
○过敏性鼻炎
○荨麻疹、湿疹/皮炎、瘙痒、皮肤瘙痒
〔孩子〕
○过敏性鼻炎
○荨麻疹、与皮肤病相关的瘙痒（湿疹/皮炎、瘙痒）
用法与用量
〔成人〕
成人常用剂量为一次0.8g（10mg 盐酸西替利嗪），每天一次，使用前溶解，睡前口服。
剂量可根据年龄和症状调整，但每日最大剂量为1.6克（盐酸西替利嗪20毫克）。
〔孩子〕
2至7岁儿童的常用剂量为一次0.2克（2.5毫克盐酸西替利嗪），每天两次，早餐后和睡前。
7至15岁儿童的常用剂量是一次0.4克（5毫克盐酸西替利嗪），每天两次，早餐后和睡前服用。
包装
0.4g×100包（2包×50）0.8g×100包（2包×50）
100g（瓶）
制造商
UCB日本有限公司
销售
第一三共有限公司
注：以上中文处方资料不够完整，使用者以原处方资料为准。
完整说明资料附件：
https://www.info.pmda.go.jp/go/pack/4490020R1027_1_10/
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Zyrtec Dry syrup 1.25%（ジルテックドライシロップ1.25％）
Brand name : Zyrtec Dry syrup 1.25%
　Active ingredient: Cetirizine hydrochloride
　Dosage form: dry syrup, white grayish white
　Print on wrapping: 5mg／包（0.4g） ジルテックドライシロップ1.25% 0.4g（1包中）
10mg／包（0.8g） ジルテックドライシロップ1.25% 0.8g（1包中）
Effects of this medicine
This medicine exhibits histamine H1 receptor antagonism and improves symptoms caused by allergy.
For adults, it is usually used to treat allergic rhinitis, hives, eczema/dermatitis, prurigo, and dermal pruritus. For children, it is usually used to treat allergic rhinitis, hives, itch of skin disorder (eczema/dermatitis, dermal pruritus).
Before using this medicine, be sure to tell your doctor and pharmacist
•If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
If you have renal or liver disorder.
If you have convulsive disorder such as epilepsy, or history of this disease.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•General dosage regimen: For adults, take 0.8g (10mg as active ingredient) once a day, before bedtime by dissolving the medicine in water just before use. The dose may be adjusted according to your age and symptoms. The dose can be increased up to 1.6g (20mg) per day according to need. For children aged between 2 to 6 years: take 0.2g (2.5mg), aged between 7 to under 15 years: take 0.4g (5mg), twice a day, after breakfast and before bedtime by dissolving the medicine in water just before use. Strictly follow the instructions of your doctor/pharmacist.
•Take the missed last dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose. DO NOT take a double dose to make up for the missed dose.
•If you took too much of this medicine (more than ordered), check with your doctor/pharmacist.
•Do not stop taking this medicine without the instructions of your doctor.
Precautions while taking this medicine
•This medicine may make you sleepy. Do not drive a car or operate dangerous machinery just after taking it.
•Drinking alcohol while taking this medicine may intensify sleepiness or lassitude.
Possible adverse reactions to this medicine
Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist:
In adults, sleepiness, lassitude, dry mouth, nausea, floating dizziness, headache, rash, etc. In chidren, sleepiness, etc.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•breathing difficulty, decrease in blood pressure, hives [shock, anaphylactoid symptoms]
•convulsion [convulsion]
•generalized fatigability, appetite loss, yellowness in the skin and the white of the eye [liver dysfunction, jaundice]
•nose/gums bleeding, subcutaneous bleeding [thrombocytopenia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from heat, moisture and direct sunlight.
•Discard the remainder. Do not store them.
DAIICHI SANKYO COMPANY, LIMITEDInternal
Revised: 5/2016
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.