LOTRISONE（克霉唑/二丙酸倍他米松[clotrimazole and betamethasone dipropionate]）霜剂/洗剂，用于局部使用
初始美国批准：1984
作用机制
克霉唑是唑类抗真菌剂[参见Clinical Pharmacology]。
二丙酸倍他米松是一种皮质类固醇。 皮质类固醇在细胞信号传导，免疫功能，炎症和蛋白质调节中起作用; 然而，用于治疗足癣，癣和体癣的精确作用机制是未知的。
适应症和用法
LOTRISONE霜剂含有克霉唑，唑类抗真菌剂和二丙酸倍他米松（一种皮质类固醇）的组合，并且用于局部治疗由于表皮癣菌，须发癣菌和红色毛癣菌的症状性炎性足癣，癣和癣的治疗患者17岁及以上。
剂量和给药
足癣：每天两次对受影响的皮肤区域涂一薄层，持续2周。
癣和癣：每天两次对受影响的皮肤区域涂一薄膜1周。
LOTRISONE霜不应在治疗癣或癣中使用超过2周，在治疗足癣时应超过4周。
除非医生指导，否则不要使用封闭敷料。
不适用于眼科，口服或阴道内。
剂量形式和强度
奶油，1％/ 0.05
每克LOTRISONE霜包含10mg的克霉唑和0.643mg的二丙酸倍他米松（相当于0.5mg的倍他米松）
禁忌症
没有。
警告和注意事项
LOTRISONE乳膏可引起可逆的HPA轴抑制，在治疗期间和之后具有糖皮质激素功能不全的可能性。危险因素是：使用高效力的局部皮质类固醇，在大表面积或闭塞区域使用，延长使用，改变皮肤屏障，肝衰竭和年龄。修改使用应该HPA轴抑制发展。
儿科患者可能更易患全身毒性。
不建议使用LOTRISONE霜治疗尿布皮炎。
不良反应
最常见的LOTRISONE霜剂的不良反应为1.9％的患者感觉到异常感觉，皮疹，水肿和继发感染各不到1％。
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=40ec029d-8af0-4f8f-bea1-1d38779ec232
Lotrisone LotionGeneric Name: Clotrimazole/Betamethasone (kloe-TRIM-a-zole/BAY-ta-METH-a-sone)Brand Name: Lotrisone
Lotrisone Lotion is used for:
Treating certain fungal skin infections, including ringworm, athlete's foot, and jock itch. It also relieves redness, swelling, and itching associated with infection.
Lotrisone Lotion is an antifungal and corticosteroid combination. It works by weakening the cell membrane of certain fungi. It also acts as an anti-inflammatory and anti-itching agent.
Do NOT use Lotrisone Lotion if:
you are allergic to any ingredient in Lotrisone Lotion
you are taking pimozide or an ergot alkaloid (eg, ergotamine)
Contact your doctor or health care provider right away if any of these apply to you.
Before using Lotrisone Lotion:
Some medical conditions may interact with Lotrisone Lotion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have diaper rash, eczema, measles, tuberculosis (TB) or a positive TB skin test, chickenpox, shingles, or thinning of the skin
if you have recently received a vaccination
Some MEDICINES MAY INTERACT with Lotrisone Lotion. Tell your health care provider if you are taking any other medicines, especially any of the following:
Clarithromycin because the risk of certain side effects may be increased
Barbiturates (eg, phenobarbital), carbamazepine, hydantoins (eg, phenytoin), or rifampin because they may decrease Lotrisone Lotion's effectiveness
Ergot alkaloids (eg, ergotamine), imatinib, live vaccines, macrolide immunosuppressants (eg, tacrolimus), pimozide, or ritodrine because their actions and the risk of their side effects may be increased by Lotrisone Lotion
Hydantoins (eg, phenytoin) or interleukin-2 because their effectiveness may be decreased by Lotrisone Lotion
This may not be a complete list of all interactions that may occur. Ask your health care provider if Lotrisone Lotion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Lotrisone Lotion:
Use Lotrisone Lotion as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Wash your hands before and after applying Lotrisone Lotion.
Shake well before each use.
Wash and completely dry the affected area.
Gently rub the medicine into the affected and surrounding areas until it is evenly distributed.
Do not bandage or wrap the affected area unless directed otherwise by your doctor.
If you are using Lotrisone Lotion in the groin area, use only for 2 weeks and apply the lotion sparingly. Wear loose-fitting clothing. Notify your doctor if your condition persists after 2 weeks.
Use Lotrisone Lotion on a regular schedule to get the most benefit from it.
To clear up your infection completely, use Lotrisone Lotion for the full course of treatment. Keep using it even if you feel better in a few days.
Notify your doctor if there is no improvement of your symptoms after 1 week of treatment on the groin or body or after 2 weeks of treatment on the feet.
If you miss a dose of Lotrisone Lotion, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
Ask your health care provider any questions you may have about how to use Lotrisone Lotion.
Important safety information:
Lotrisone Lotion is for external use only. Avoid getting Lotrisone Lotion in the eyes, vagina, mouth, or nose. If Lotrisone Lotion gets in the eyes, immediately wash out with cool tap water.
Lotrisone Lotion has a corticosteroid in it. Before you start any new medicine, check the label to see if it has a corticosteroid in it too. If it does or if you are not sure, check with your doctor or pharmacist.
Be sure to use Lotrisone Lotion for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The fungus could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
Do NOT use more than the recommended dose or use for longer than prescribed without checking with your doctor.
Do not apply Lotrisone Lotion over large areas of the body without first checking with your doctor.
Do not use Lotrisone Lotion for other skin conditions at a later time.
Talk with your doctor before you use any other medicines or cleansers on your skin.
Do not use Lotrisone Lotion for diaper rash.
Serious side effects may occur if too much of Lotrisone Lotion is absorbed through the skin. This may be more likely to occur if you use Lotrisone Lotion over a large area of the body. It may also be more likely if you wrap or bandage the area after you apply Lotrisone Lotion. The risk is greater in children. Do not use more than the prescribed dose. Contact your doctor right away if you develop unusual weight gain (especially in the face), muscle weakness, increased thirst or urination, confusion, unusual drowsiness, severe or persistent headache, or vision changes. Discuss any questions or concerns with your doctor.
Use Lotrisone Lotion with caution in the ELDERLY; they may be more sensitive to its effects, especially thinning skin.
Corticosteroids may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while using a corticosteroid.
Lotrisone Lotion should not be used in CHILDREN younger than 17 years old; safety and effectiveness in these children have not been confirmed.
PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Lotrisone Lotion while you are pregnant. It is not known if Lotrisone Lotion is found in breast milk. If you are or will be breast-feeding while you use Lotrisone Lotion, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Lotrisone Lotion:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Dry skin; mild burning or stinging at the application site.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); acne-like rash; excessive hair growth; inflamed hair follicles; inflammation around the mouth; irritation, itching, peeling, redness, blistering, swelling, oozing, or severe burning at the application site; spider veins; thinning, softening, or discoloration of the skin; unusual bruising.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Lotrisone Lotion may be harmful if swallowed.
Proper storage of Lotrisone Lotion:
Store Lotrisone Lotion at 77 degrees F (25 degrees C) in the upright position only. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Store Lotrisone Lotion away from products used in the eyes or ears to avoid using Lotrisone Lotion incorrectly. Keep Lotrisone Lotion out of the reach of children and away from pets.
General information:
If you have any questions about Lotrisone Lotion, please talk with your doctor, pharmacist, or other health care provider.
Lotrisone Lotion is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.
This information is summary only. It does not contain all information about Lotrisone Lotion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.