药效药理
洛索普罗芬钠水合物从皮肤吸收后，转化为活性代谢物转-OH体，急性炎症和慢性炎症，对疼痛，表现出优异的抗炎和镇痛作用。
1. 抗炎作用
洛索普罗芬钠水合物的帕普剂，卡拉格宁水肿是一种急性炎症模型（大鼠），对佐剂关节炎（大鼠）是慢性炎症模型表现出显著的抗炎作用。
2. 镇痛作用
洛索普罗芬钠水合物的帕普剂，在兰达塞利特法（大鼠）中表现出镇痛作用。 此外，它表现出镇痛作用，对佐剂慢性关节炎疼痛（大鼠）。
适应症
抗炎/镇痛有以下疾病和症状
骨关节炎，肌肉疼痛，创伤后肿胀·疼痛
用法与用量
根据症状，每天数次在受影响的区域涂抹适量
包装
凝胶 1%
25g×10
50g×10
制造商/销售
第一三共株式会社 注：以上产品资料不够完整，使用者以原处方资料为准。
完整说明资料附件： https://www.info.pmda.go.jp/go/pack/2649735Q1020_1_09/
LOXONIN GEL 1%（Loxoprofen sodium hydrate）
Brand name :LOXONIN GEL 1%
Active ingredient:Loxoprofen sodium hydrate
Dosage form:clear, colorless to faint yellow jellylike gel
Print on wrapping:ロキソニンゲル1％, 25g, 50g, LOXONIN, 経皮吸収型鎮痛・抗炎症剤
Effects of this medicine
This medicine permeates from the skin, suppresses prostaglandin formation that causes inflammation, and acts to ease swelling/pain induced by inflammation.
It is usually used to treat osteoarthritis, muscle pain, swelling/pain after an injury.
Before using this medicine, be sure to tell your doctor and pharmacist
If you have previously experienced any allergic reactions (itch, rash, etc) to any medicines.
If you have: aspirin-induced asthma or its history.
If you are pregnant or breastfeeding.
If you are taking any other medicinal products.(Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
Your dosing schedule prescribed by your doctor is((to be written by a healthcare professional))
In general, apply and rub an appropriate amount according to the symptom several times a day. Strictly follow the instructions.
If you miss a dose, apply the missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never apply double doses at one time.
If you accidentally use more than your prescribed dose, consult with your doctor or pharmacist.
Do not stop using this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
Never put this product close to fire as it contains alcohol.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include itch, erythema, contact dermatitis, and gastric discomfort. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
facial pallor, breathing difficulty, cold sweat [shock, anaphylaxis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
Keep out of reach of children. Store away from direct sunlight, heat, moisture, and fire as it contains alcohol.
Discard the remainder. Do not store them.
External
Revised: 8/2017
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
