ORTHOVISC（Hyaluronan 高分子量透明质酸）是FDA批准的唯一一种由超纯透明质酸制成的治疗方法，用于健康的膝关节。 这种膝关节疼痛注射也是唯一提供缓解的治疗方法。
ORTHOVISC高分子量透明质酸
说明
QRTHOVISCO是一种无菌，无热原，透明，粘稠的透明质酸溶液。
一次性注射器。ORTHOVISCO（1.0-2.9百万道尔顿），超纯天然透明质酸溶于生理盐水。透明质酸是一种天然的复合物
糖胺聚糖家族的糖。透明质酸是从公鸡梳子中提取的。
适应症
ORTHOVISC®表示在骨关节炎（OA）的膝盖的疼痛治疗中谁没有回应保守治疗非药物并充分执行简单的止痛药的患者，E.G.对乙酰氨基酚。
禁忌症
*不要给已知对透明质酸制剂过敏（过敏）的患者服用。
*不要对已知对禽类或禽类衍生产品（包括鸡蛋，羽毛或家禽）过敏的患者给药。
*不要将ORTHOVISO®注射到患有感染或皮肤病的患者的膝盖中
注射部位或关节的区域。
警告
*不要同时使用含有季铵盐的消毒剂
制备透明质酸可在其存在下沉淀。 *一些炎性骨关节炎患者报告了注射QRTHOVISC®后注射膝关节炎症的短暂增加。
包装
ORTHOVISC 15MG/1ML 2ML PF SYR 1/EA  HYALURONIC ACID  DEPUY SYNTHES SALES INC.NDC：59676-0360-01
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rthovisc Generic Name: Hyaluronan (hye-a-loo-ROE-nan)Brand Name: Orthovisc
Orthovisc is used for:
Treating knee pain in patients with osteoarthritis who have not received relief from other treatments.
Orthovisc is a hyaluronic acid derivative. It works by increasing the effectiveness of the fluid within the knee joint to act as a lubricant and shock absorber.
Do NOT use Orthovisc if:
you are allergic to any ingredient in Orthovisc or to birds or bird products (eg, eggs, feathers, poultry)
you have an infection or skin disease near the joint or injection site
Contact your doctor or health care provider right away if any of these apply to you.
Before using Orthovisc :
Some medical conditions may interact with Orthovisc . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
Some MEDICINES MAY INTERACT with Orthovisc . Tell your health care provider if you are taking any other medicines, especially any of the following:
Quaternary ammonium salts because side effects may occur
This may not be a complete list of all interactions that may occur. Ask your health care provider if Orthovisc may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Orthovisc :
Use Orthovisc as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Orthovisc comes with an additional patient leaflet. Read it carefully and reread it each time you get Orthovisc refilled.
Orthovisc is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Orthovisc at home, carefully follow the injection procedures taught to you by your health care provider.
If Orthovisc contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
Do not use disinfectants containing ammonium salts to prepare the skin for injection because side effects may occur.
Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
If you miss a dose of Orthovisc , contact your doctor to establish a new dosing schedule.
Ask your health care provider any questions you may have about how to use Orthovisc .
Important safety information:
Orthovisc is usually given as a series of injections 1 week apart for a total of 3 or 4 injections. You may not experience pain relief until after the third injection.
You may experience a temporary inflammation in your knee after using Orthovisc . If the inflammation is severe or continues, contact your doctor.
Avoid strenuous activity or prolonged (more than 1 hour) weight-bearing activity (eg, running, tennis, heavy lifting) for at least 48 hours after you are injected with Orthovisc .
Use Orthovisc with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Orthovisc , discuss with your doctor the benefits and risks of using Orthovisc during pregnancy. It is unknown if Orthovisc is excreted in breast milk. If you are or will be breast-feeding while you are using Orthovisc , check with your doctor or pharmacist to discuss the risks to your baby.
Possible side effects of Orthovisc :
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Mild bruising, heat, redness, swelling, or pain at the injection site; temporary achy feeling; temporary knee inflammation.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).
https://www.accessdata.fda.gov/cdrh_docs/pdf3/P030019c.pdf