Product Description
What are the indications and usage?
Teysuno is a medicine that contains the active substa nces tegafur, gimeracil and oteracil. It is available as capsules containing 15 mg tegafur with 4.35 mg gimeracil and 11.8 mg oteracil, and as capsules containing 20 mg tegafur with 5.8 mg gimeracil and 15.8 mg oteracil.
Teysuno is used to treat adults with advanced gastric (stomach) cancer. It is used in combination with cisplatin (another anticancer medicine). The medicine can only be obtained with a prescription
What is it and how is it used?
Teysuno belongs to the fluoropyrimidine class of medicine known as ?antineoplastic agents? which stop the growth of cancer cells.
Teysuno is prescribed by doctors for the treatment of adults with advanced stomach (gastric) cancer and is taken with cisplatin, another anti-cancer medicine.
What do you have to consider before using it?
Do not take Teysuno if you:
■are allergic (hypersensitive) to tegafur, gimeracil, oteracil or any of the other ingredients of Teysuno
■are taking other fluoropyrimidine anti-cancer medicine such as fluorouracil and capecitabine, or have had severe and unexpected reactions to fluoropyrimidines
■have known genetic deficiency of the enzyme dihydropyrimidine dehydrogenase (DPD)
■are pregnant or breastfeeding
■have severe blood disorders
■have severe kidney problems
■are currently being treated or have been treated in the last 4 weeks with sorivudine, brivudine or a similar class of anti-viral medicines
Take special care with Teysuno
■Before treatment with Teysuno, tell your doctor if you have:
■blood disorders
■kidney disease
■stomach and/or bowel problems such as pain, diarrhoea, vomiting and dehydration
■eye disorders, such as ?dry eye? or increased tearing
■Teysuno is not recommended for children under 18 years of age.
■Teysuno cannot be substituted for other oral fluoropyrimidine medicine.
Taking other medicines
Before starting treatment, please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. This is extremely important, as taking more than one medicine at the same time can strengthen or weaken the effect of the medicines. You need to be particularly careful if you are taking any of the following:
■other fluoropyrimidine based medicines such as the anti-fungal flucytosine
■antivirals such as brivudine or sorivudine
■inhibitors of the enzyme CYP2A6 which activates Teysuno such as tranylcypromine and methoxsalen
■folinic acid (often used in chemotherapy with methotrexate)
■blood-thinning medicines: coumarin-derivative anticoagulants such as warfarin
■medicines for the treatment of seizures or tremors such as phenytoin
■medicines that treat gout such as allopurinol
Taking Teysuno with food and drink
Teysuno should be taken at least one hour before or one hour after a meal.
Pregnancy and breastfeeding
Before starting treatment, you must tell your doctor or pharmacist if you are pregnant, if you think you are pregnant, or if you intend to become pregnant. You must not take Teysuno if you are pregnant or think you might be.
During and up to 6 months after treatment with Teysuno, you must use contraceptive measures. If you become pregnant during this time, you must tell your doctor.
You must not breastfeed if you are taking Teysuno.
Ask your doctor or pharmacist for advice before taking any medicine.
Driving and using ma |
