The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse effects (risks) as well as efficacies (benefits). It is important to minimize adverse effects and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name : DIAMOX Tablets 250mg
Active ingredient: Acetazolamide
Dosage form: white tablet, with a split line, φ11.1mm, thickness 4.6mm
Print on wrapping: DIAMOX250, DMX250, Sc237, ダイアモックス錠250mg, ダイアモックス, 250mg
Effects of this medicine
This medicine inhibits carbonic anhydrase and increases the amount of oxygen in the blood, and consequently improves acidosis and sleep apnea, lowers intraocular pressure, suppresses epileptic seizure, relieves swelling by increasing urine output, improves Meniere's syndrome, eases premenstrual syndrome, etc.
It is usually used for the treatment of glaucoma, epilepsy, respiratory acidosis in emphysema, cardiac edema, hepatic edema, premenstrual syndrome, Meniere's disease and syndrome, and sleep apnea syndrome.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you ever experienced any allergic reaction (itch, rash, etc.) to any medicine.
If you are a patient with liver disorder or dysfunction, anuria, kidney disorder, hyperchloremic acidosis, adrenal insufficiency, Addison's disease, glaucoma.
If you are decreased of sodium or potassium in body fluids.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is << to be written by a healthcare professional>>
•General dosage regimen:
For the treatment of glaucoma, for adults, take 1-4 tablets (250-1,000mg of the active ingredient) daily, in divided doses.
For the treatment of epilepsy, for adults, take 1-3 tablets (250-750mg of the active ingredient) daily, in divided doses.
For improvement of respiratory acidosis in emphysema, for the treatment of cardiac edema and hepatic edema, for adults, take 1-2 tablets (250-500mg of the active ingredient) once daily.
For the treatment of premenstrual syndrome, for adults, take 0.5-1.5 tablets (125-375mg of the active ingredient) once daily, for 5-10 days before a menstrual period begins or on the day that symptoms developed.
For the treatment of Meniere's disease and syndrome, for adults, take 1-3 tablets (250-750mg of the active ingredient) once daily.
For the treatment of sleep apnea syndrome, for adults, take 1-2 tablets (250-500mg of the active ingredient) daily, in divided doses.
The dosage may be adjusted according to the age or symptoms in any cases. Strictly follow the instructions of your doctor/pharmacist.
•Take a dose as soon as possible when you remembered that you missed a dose. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. DO NOT take double doses to make up for the missed dose.
•If you took too much of the medicine (more than ordered), check with your doctor/pharmacist.
•Do not stop taking the medicine without the instructions of your doctor.
Precautions while taking this medicine
•You may feel dizziness/stagger. Do not drive a car, work at heights, or operate dangerous machinery while taking this medicine.
Possible adverse effects of this medicine
Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: paresthesia (numbness), frequent urination/polyuria, rash, fever, etc.
The symptoms described below are rarely seen as initial symptoms of the adverse effects indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•generalized fatigability, hands/feet tremor, hyperpnea(over breathing)[metabolic acidosis, electrolyte abnormality]
•facial pallor/flop sweat, breathing difficulty, hives [shock, anaphylactoid symptoms]
•fever, pharyngitis, flu-like symptom [aplastic anemia, hemolytic anemia, agranulocytosis]
•nasal bleeding, gum bleeding, increase in amount of menstrual bleeding, subcutaneous hemorrhage in the limbs, etc. [thrombocytopenic purpura]
•fever, redness/sores of mucous membrane, erythema [Stevens-Johnson syndrome, toxic epidermal necrolysis]
•decrease of urine output, swelling, hematuria [acute renal failure, nephrolithiasis, urolithiasis]
•difficulty in thinking, hallucination, spasmodically contracting in muscle [delirium, convulsion]
•generalized fatigability, nausea, yellowness in skin or conjunctiva[liver disorder, jaundice]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
• Discard the remainder. Do not store them.
