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The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
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Brand name :
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GRAZYNA Tablets 50 mg
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Dosage form:
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white tablet with gray flecks, major axis: 13.89 mm, minor axis: 6.73 mm, thickness: 5.65 mm
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Print on wrapping:
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（Face）GRAZYNA 50mg, 779, グラジナ 50mg
（Back）グラジナ 50mg
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Effects of this medicine
This medicine inhibits proteases involved in hepatitis C virus replication, thereby suppressing hepatitis C virus multiplication (antiviral action). It is used with elbasvir.
It is usually used to treat chronic hepatitis C or compensated cirrhosis type C.
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Before using this medicine, be sure to tell your doctor and pharmacist
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If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have liver dysfunction.
If you have ever diagnosed as hepatitis B.
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If you are pregnant or breastfeeding.
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If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
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Dosing schedule (How to take this medicine)
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Your dosing schedule prescribed by your doctor is (( to be written by a healthcare professional))
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In general, for adults, take 2 tablets (100 mg of grazoprevir) at a time, once a day, for 12 weeks. Strictly follow the instructions.
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This medicine is used concomitantly with elbasvir. Follow the instruction about elbasvir.
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Remove the medicine from a press-through package (PTP) immediately before use.
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If you miss a dose, consult with your doctor or pharmacist. You should never take two doses at one time.
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If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
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Do not stop taking this medicine unless your doctor instructs you to do so.
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Precautions while taking this medicine
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Avoid taking any food containing St. John's wort, since it may decrease the blood level of the medicine and diminish medicinal effects.
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Possible adverse reactions to this medicine
The most commonly reported adverse reactions include headache, general malaise, diarrhea, constipation and rash. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
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general malaise, loss of appetite, nausea/vomiting [liver dysfunction]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
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Storage conditions and other information
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Keep out of reach of children. Store away from direct sunlight, heat and moisture.
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Do not take the tablets out of the PTP sheet to avoid moisture.
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Discard the remainder. Do not store them.
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