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The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
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Dosage form:
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white to brownish white powder
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Print on wrapping:
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プロナーゼMS, PRONASE MS, KC-655, 20,000単位/包（0.5g）
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Effects of this medicine
This medicine is protease which breaks the bond of peptides which are the main components of gastric mucus. It will break down and remove gastric mucus.
It is usually used to lyse and remove gastric mucus in gastroscopy, then it is easily to diagnose using endoscope.
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Before using this medicine, be sure to tell your doctor and pharmacist
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If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have inner stomach bleeding (blood vomiting/melena).
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If you are pregnant or breastfeeding.
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If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
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Dosing schedule (How to take this medicine)
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Your dosing schedule prescribed by your doctor is << to be written by a healthcare professional>>
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In general, dissolve 0.5 g (20,000 units of the active ingredient) in 50 to 80 mL of water with 1 g of sodium bicarbonate and take it 15 to 30 minutes before gastroscopy. Strictly follow the instructions.
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If you miss a dose, consult with your doctor or nurse before gastroscopy. You should not take two doses at one time.
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If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
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Do not stop taking this medicine unless your doctor instructs you to do so.
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Precautions while taking this medicine
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Possible adverse reactions to this medicine
The most commonly reported adverse reactions include stomach bleeding. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
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respiratory distress, general flushing, edema [shock, anaphylactoid symptoms]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
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Storage conditions and other information
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Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
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Discard the remainder. Do not store them.
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