Effects of this medicine

Before using this medicine, be sure to tell your doctor and pharmacist

• If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
  If you have myelosuppression, diarrhea, complication of infection, ascites, pleural effusion, heart disease or a history of it, poor general condition.
  If you are receiving the combination preparation of Tegafur, Gimeracil and Oteracil Potassium or had discontinued receiving it within 7 days.
  If you have hepatic disorder, renal disorder, hepatic metastasis.
  If you have gastrointestinal ulcer or haemorrhage.
  If you are receiving radiotherapy.

• If you are pregnant or breastfeeding.

• If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

• Your dosing schedule prescribed by your doctor is <<        to be written by a healthcare professional>>

• In general, this medicine is administered by intravenous drip infusion at one time over the period of 2 hours.
• Duration of administration may vary by other concomitant drug and your condition. Ask your doctor about your dosing schedule.

Precautions while taking this medicine

• Treatment with this medicine may cause decreased bone-marrow function. If you have decreased bone-marrow function, infection or bleeding may tend to occur. However, it is difficult to find out these symptoms so that you should receive clinical examination (blood test, liver/renal function test, etc) regularly (frequently during early treatment period, in particular) to find any symptoms early.

Possible adverse reactions to this medicine

• intense abdominal pain, diarrhea, hematochezia [serious enterocolitis]
• general malaise, bruise, dizziness [myelosuppression]
• rash, breathing difficulty, decreased blood pressure [shock, anaphylaxis]
• unsteady gait, numbness of terminal portion of extremities, impaired tongue movement [leukoencephalopathy, mental/nerve disorder]
• chest pain, cold sweat, feeling of strong pressure in chest [congestive heart failure, myocardial infraction, angina at rest]
• general swelling, fatigability, difficulty in urination [acute renal failure]
• fever, dry cough, difficult to breathe [interstitial pneumonia]
• general malaise, loss of appetite, yellowing in skin and white of eyes [hepatic function disorder, jaundice]
• nausea, vomiting, gastric pain, oral erosion and pain [gastrointestinal ulcer, serious stomatitis]
• sudden intense pain in low back and back , fever, nausea, vomiting [acute pancreatitis]
• impaired consciousness, flapping tremor in hands, tremor in limbs [hyperammonemia]
• hypesthesia and supersensitivity, pain, skin exfoliation in volar [hand-foot syndrome]
• difficult to smell, feel no smell [anosmia]
• sweating, intense abdominal pain, watery stool [severe diarrhea]
• nasal bleeding, palpitation, shortness of breath, bruise, yellow urine [disseminated intravascular coagulation]