Effects of this medicine

Before using this medicine, be sure to tell your doctor and pharmacist

• If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
  If you are a patient with hepatic/renal disorder or hypervitaminosis A.
  If you are predisposed to have hypertriglyceridemia. (For example, you have diabetes, obesity, alcoholism or lipid metabolism abnormality.)

• If you are pregnant or breastfeeding.

• If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

• Your dosing schedule prescribed by your doctor is <<        to be written by a healthcare professional>>

• General dosage regimen: For adults, in order to induce a remission, take 40-50mg of the active ingredient in 2-3 divided doses a day for 2-4 weeks. The maximum daily dosage is 75mg of the active ingredient. After that, in order to maintain remission, take 10-30mg of the active ingredient in 1-3 divided doses a day according to the patient's symptoms.
  For infants and children, in order to induce a remission, take 1.0mg/kg of the active ingredient in 1-3 divided doses a day for 2-4 weeks. After that, in order to remain remission, take 0.6-0.8 mg/kg of the active ingredient in 1-3 divided doses a day according to the patient's symptoms.
  It should be adjusted according to your disease, age and symptoms in any case.
  1 capsule contains 25mg of the active ingredient. Strictly follow the instructions of your doctor/pharmacist.
• Avoid taking this medicine with a great amount of milk or fatty food.

• Take the missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. DO NOT take a double dose to make up for the missed dose.

• If you took too much of this medicine (more than ordered), check with your doctor/pharmacist.

• Do not stop taking this medicine without the instructions of your doctor.

Precautions while taking this medicine

• This medicine has teratogenic potential (possibility to cause fetal anomaly) and has a higher incidence of side effects. You need to be informed of the side effects until you fully understand them.
• In using this medicine, you need to be informed of precautions mentioned below until you fully understand them. If you agree to them, sign the letter of consent.
• If you have a possibility of pregnancy, you have to wait a few days after your menstruation begins before taking this medicine. Also, you may have a pregnancy test within 2 weeks before taking this medicine.
• If you have a possibility of pregnancy, make sure to avoid pregnancy during use and for at least 2 years after withdrawal of this medicine.
• A male patient must avoid pregnancy during use and for at least 6 months after withdrawal of this medicine.
• You cannot make a blood donation during use and for at least 2 years after withdrawal of this medicine.
• When you have joint/bone pain, contact your doctor immediately. Also, if you are supposed to take this medicine for a long period, you may have to take an X-ray examination, etc.
• This medicine may cause liver damage. For the early detection of the side effects, your liver function will be checked before and 1 month after starting this medication, and also every 3 months during use. Do not forget to undergo it on each designated date.
• A patient with hypertriglyceridemia tends to have lipid metabolism abnormality. So, blood test will be conducted to the patient.
• This medicine may cause hair loss, cheilitis, or desquamation (peeled surface skin).
• Avoid breastfeeding.

Possible adverse reactions to this medicine

• joint pain, sore red skin, red spots and breakable blisters all over the body, lassitude [toxic epidermal necrosis (Lyell syndrome)]
• rash and blister, joint pain, fever [erythema multiforme]
• angialgia, purple bruise, swelling [vasculitis]

Storage conditions and other information

• Keep out of the reach of children. Store at room temperature (1-30℃), away from light and moisture.
•  Discard the remainder. Do not store them. Ask the pharmacist how to discard.