Effects of this medicine

Before using this medicine, be sure to tell your doctor and pharmacist

• If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
  If you have difficulty in swallowing foods/medicines or hypocalcemia.
  If you are not able to keep an upright position for at least 30 minutes.

• If you are pregnant or breastfeeding.

• If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

• Your dosing schedule prescribed by your doctor is <<        to be written by a healthcare professional>>

• In general, for adults, take 1 packet (35 mg of Alendronate) at a time, once a week at the time of awakening (before breakfast) with a glass of water (approximately 180 mL). Strictly follow the instructions.
• Take this medicine on the morning of the same day of the week every week.
• Do not take this medicine with fluids other than water (never with mineral water with a high calcium/magnesium content, tea, coffee, juice, milk, etc.). Do not chew/suck the medicine or dissolve it in mouth. If chewed, drink water and rinse your mouth to prevent jelly fragments from remaining in your mouth.
• Do not eat/drink (except water) or take other medicine at least 30 minutes after taking this medicine. Do not lie down for at least 30 minutes after taking this medicine, and keep your body in an upright position until you finish the first meal of the day. Do not take this medicine at bedtime or before waking up.
• Open the packet and take the contents only. Take the medicine immediately after opening the packet and discard the remainder. Do not take it besides oral administration.

• If you miss a dose, take the missed dose the next morning (the dosage regimen is same as usual), and continue your regular dosing schedule. You should never take two doses at one time.

• If you accidentally took your dose two days in a row or took 2 packets at once, skip the next scheduled dose and return to your regular dosing schedule from the next time. If you notice any abnormality, consult with your doctor or pharmacist.

• Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

• Maintain your oral hygiene while taking this medicine.
• When you receive dental treatment such as tooth extraction or implant, tell your dentist or oral surgeon that you are taking this medicine.
• Try to ingest calcium through meals, etc.
• Consult with your doctor of pharmacist before taking supplements containing calcium or vitamin D.

Possible adverse reactions to this medicine

• difficulty in swallowing, pain on swallowing, chest (underside of the breastbone) pain [esophageal/intraoral disorder]
• vomiting of blood, melena (black stool), pain in the pit of stomach [gastric/duodenum disorder]
• high fever, general malaise, lip erosion, bloodshot eyes, sore throat, red rash/bulla in wide area of skin [toxic epidermal necrolysis, mucocutaneous ocular syndrome]
• jaw pain/swelling/numbness, loose tooth [jaw bone necrosis, jaw osteomyelitis]
• pain of the thigh or inguinal region [atypical subtrochanteric and diaphyseal femoral fractures]

Storage conditions and other information

• Keep out of the reach of children. Store away from direct sunlight, heat, freezer and refrigerator.
• Do not take it if white clots are seen.
• Do not put heavy things on it.
• Pay attention not to fold it when carrying.
•  Discard the remainder. Do not store them. Ask the pharmacist and the medical institution how to discard them.