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Otsuka Pharmaceutical Co., Ltd.
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The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
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Brand name :
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Pletaal Powder 20 %
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Dosage form:
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White powder
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Print on wrapping:
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プレタール散20% 50mg/1包 (0.25g) or 100mg/1包 (0.5g)
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Effects of this medicine
This medicine inhibits the platelet aggregation induced by thromboxane A2 and inhibits the phosphodiesterase 3 (PDE3) activity of platelets and vascular smooth muscle, thus exerting an antiplatelet and vasodilative action and consequently improving blood flow.
It is usually used to improve symptoms such as ulcer, pain and coldness attributed to chronic arterial occlusion, and to prevent recurrence of cerebral infarction.
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Before using this medicine, be sure to tell your doctor and pharmacist
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If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you are bleeding (hemophilia, capillary fragility, hemoptysis, intracranial bleeding, bleeding from the gastrointestinal tract or urinary tract, bleeding in vitreous body, etc.).
If you have congestive heart failure.
If you are scheduled to undergo surgery or tooth extraction.
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If you are pregnant or breastfeeding.
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If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
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Dosing schedule (How to take this medicine)
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Your dosing schedule prescribed by your doctor is << to be written by a healthcare professional>>
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In general, for adults, take 0.5 g (100 mg of active ingredient) at a time, twice daily. The dosage may be adjusted according to your disease, age or symptoms. Strictly follow the instructions.
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You may swallow this medicine with saliva after soaking the powder with saliva on the tongue. You may also take this medicine with a cup of cold or lukewarm water.
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You should not take this medicine while in a lying-down position.
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If you miss a dose, take the dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
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If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
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Do not stop taking this medicine unless your doctor instructs you to do so.
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Precautions while taking this medicine
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Do not take this medicine with grapefruit juice since it may enhance the effects of this medicine.
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This medicine makes it more difficult for blood to clot. If you are bleeding lasting for several hours or an injury involving a large area of your body, immediately visit a nearby hospital.
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If you receive any treatment by another doctor including dental treatment, tell the doctor or dentist that you are taking this medicine.
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Possible adverse reactions to this medicine
The most commonly reported adverse reactions include headache, headache dull, tachycardia, abdominal pain, nausea or vomiting, dizziness, palpitation, diarrhea, rash, hepatic dysfunction, anemia, arrhythmia such as atrial fibrillation, supraventricular tachycardia, supraventricular extrasystole or ventricular extrasystole, eruption, itch, hives, photosensitivity and erythema. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
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Respiratory distress, general swelling, sudden onset of precordial chest pressure sensation or chest pain, pulse rate increased (more than 100 beats/min) [congestive heart failure, myocardial infarction, angina pectoris, ventricular tachycardia]
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Headache, consciousness disorder, abdominal pain [bleeding (bleeding intracranial such as cerebral bleeding, pulmonary bleeding, gastrointestinal bleeding, nasal bleeding, fundal bleeding, etc.) ]
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Headache, throat pain, muscular pain, high fever with chills and shivering [pancytopenia, agranulocytosis, thrombocytopenia]
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Fever, dry cough, respiratory distress [interstitial pneumonia]
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General malaise, loss of appetite, yellowing in skin and white of eyes [hepatic dysfunction, jaundice]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
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Storage conditions and other information
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Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
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If there is a remainder, this is to be discarded. Do not store it.
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