Pfizer Pharmaceuticals Inc.
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The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
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Brand name :
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Inlyta tablets 5mg
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Dosage form:
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red tablet, major axis: 7.7 mm, thickness: 3.8 mm
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Print on wrapping:
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インライタ5mg, Pfizer 5XNB, インライタ 5 Inlyta
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Effects of this medicine
This medicine has an anti-tumor effect inhibiting angiogenesis and suppressing the tumor cell growth and metastasis by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, -2, and -3).
Usually, used for treatment of radically unresectable or metastatic renal cell carcinoma.
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Before using this medicine, be sure to tell your doctor and pharmacist
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If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
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If you are pregnant, breastfeeding or possibly pregnant.
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If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
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Dosing schedule (How to take this medicine)
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Your dosing schedule prescribed by your doctor is << to be written by a healthcare professional>>
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In general, for adults, take 1 tablet (5 mg of the active ingredient) at a time twice a day. The dosage may be adjusted according to the patient's symptoms. However, the daily dosage is up to 2 tablets (10 mg) at a time twice a day. Strictly follow the instructions.
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If you miss a dose, take the missed dose as soon as possible. However, you should take the missed dose by three hours before the next dosing schedule or skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
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If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
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Do not stop taking this medicine unless your doctor instructs you to do so.
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Precautions while taking this medicine
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Avoid taking food containing St. John's wort (a kind of herb) with the medicine, because the effect of the medicine may be decreased.
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Avoid drinking grapefruit juice with the medicine, because the effect of the medicine may be increased.
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Possible adverse reactions to this medicine
The most commonly reported adverse reactions include diarrhea, constipation, vomiting, nausea, abdominal pain, stomatitis, hypertension, dysphonia, cough, loss of appetite, hand-and-foot syndrome (tingling, hot flash, swelling), rash, dry skin, joint pain, fatigue, asthenia, decreased weight, mucosal inflammation, chest pain, dullness, headache, hypothyroidism, dysgeusia, nasal bleeding and edema. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
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headache, fever, sudden increase in blood pressure [hypertension, high blood pressure crisis]
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decreased sweating, bradycardia, dry skin, sweating, tachycardia [thyroid dysfunction]
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nasal bleeding, hematuria, black stool [hemorrhage]
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severe abdominal pain, melena, hematemesis [perforation of the digestive tract, fistula formation]
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dullness (general), loss of appetite, yellowing of the skin or whites of the eyes [liver dysfunction]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
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Storage conditions and other information
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Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
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Discard the remainder. Do not store them. If you dispose of unused medicines, seek advice of your pharmacist about proper disposal of drugs.
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