Meiji Seika Pharma Co., Ltd.
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The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
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Brand name :
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DIACOMIT CAPSULES 250mg
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Dosage form:
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bright purplish red capsule, major axis: 18.1 mm, minor axis: 6.1 mm
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Effects of this medicine
This medicine reduces excessive excitation of the nerves in the brain to help control epileptic seizures.
It is usually used together with other medicines to treat clonic seizures or tonic-clonic seizures in Dravet syndrome.
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Before using this medicine, be sure to tell your doctor and pharmacist
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If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have liver dysfunction, renal dysfunction, blood disorder, respiratory disease, or QT prolongation (abnormal electrocardiogram).
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If you are pregnant or breastfeeding.
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If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
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Dosing schedule (How to take this medicine)
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Your dosing schedule prescribed by your doctor is << to be written by a healthcare professional>>
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For patients aged 1 year or older (weighing less than 50 kg): In general, take 50 mg/kg of the active ingredient a day in 2 or 3 divided doses at or just after a meal. When taking this medicine for the first time, start with 20 mg/kg a day and then the dosage will be increased by 10 mg/kg at every intervals of 1 week or longer up to 50 mg/kg a day. The maximum daily dose is 50 mg/kg.
For patients aged 1 year or older (weighing 50 kg or more): In general, take 1,000 mg/kg of the active ingredient a day in 2 or 3 divided doses at or just after a meal. The dosage will be increased by 500 mg/kg at every intervals of 1 week or longer. The maximum daily dose is 2,500 mg/kg.
This medicine is used concomitantly with other antiepileptic medicine. This preparation contains 250 mg of the active ingredient in a capsule. In any case, strictly follow the instructions.
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If you miss a dose, take the missed dose with a snack as soon as possible; however, do not take with any caffeine-containing food such as chocolate. Let at least 4 hours pass between doses. You should never take two doses at one time.
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If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
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Do not stop taking this medicine unless your doctor instructs you to do so.
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Precautions while taking this medicine
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This medicine may cause decreased appetite and weight decrease. If any such sign appears, please consult with your doctor or pharmacist.
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This medicine may cause sleepiness and depression of your attentiveness, concentration and reflexive motor function. Avoid driving a car or operating dangerous machinery.
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Take care in taking this medicine with caffeine-containing food (e.g., chocolate, coffee, tea, green tea, or coke) since it may intensify the effects of caffeine.
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Be moderate in drinking alcohol since it affects the effects of this medicine.
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Possible adverse reactions to this medicine
The most commonly reported adverse reactions include somnolence, decreased appetite, ataxia (light headedness) and tremor (trembling). If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
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fever, sore throat, nose bleeding, gum bleeding, subcutaneous bleeding [neutropenia, thrombocytopenia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
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Storage conditions and other information
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Keep out of reach of children. Store away from direct sunlight, heat and moisture.
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Make sure to store this medicine in a tightly sealed container after use. If you are taking this medicine outside your home (e.g., to school or on a trip), place this medicine in a tightly sealed container.
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When this medicine is dispensed in repacking bottles, be sure to take each dose from the repacking bottle.
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Discard the remainder. Do not store them. Seek advice of your pharmacy or medical institution about proper disposal of the unused medicines
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