Effects of this medicine

Before using this medicine, be sure to tell your doctor and pharmacist

• If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
  If you have or have previously experienced heart disease.
  If you have been previously diagnosed with high blood pressure or hypertension.
  If you are having difficulty breathing even at rest or have previously experienced such a symptom.
  If you are treated with radiation therapy.
  If you have previously been treated with anthracycline drugs.

• If you are pregnant or breastfeeding.

• If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

• Your dosing schedule prescribed by your doctor is <<        to be written by a healthcare professional>>

• For breast cancer: In general, administer by intravenous infusion once a day at an interval of once every week or every three weeks.
  For advanced or recurrent gastric cancer, not amenable to curative resection: In general, administer by intravenous infusion once a day at an interval of every three weeks.
• Dosage and treatment interval depend on the results from checking on the patient's conditions.

Precautions while taking this medicine

• Since serious cardiac disorder such as cardiac failure may occur, your cardiac function may be checked by echocardiography.
• If you have a possibility of pregnancy, avoid pregnancy while you are taking this medicine. Also avoid pregnancy for at least seven months after you discontinue this medicine.

Possible adverse reactions to this medicine

• fever, general dullness, dizziness on standing up, dizziness, swelling, easy breathing in upright position, breathlessness, shortness of breath, chest pain, pounding heart, palpitation, irregular heartbeat, slow pulse, nausea, vomiting, loss of appetite, impaired judgment/mind, decreased/confused consciousness, loss of consciousness [cardiac disorder]
• general dullness, lightheadedness, decreased consciousness, impaired judgment/mind, glow, swelling around the eye and lips, hoarseness, breathing difficulty, shortness of breath, palpitation, hives [anaphylactoid symptoms]
• chills, fever, cough, phlegm, breathing difficulty, shortness of breath, rapid breathing with difficulty, pale lips, pale nails on limbs [interstitial pneumonia, pulmonary disorder]
• fever, sore throat, nose bleeding, gum bleeding, subcutaneous bleeding, blue spot, continuous bleeding, general dullness, dizziness, headache, ear ringing, palpitation, shortness of breath [leukopenia, neutropenia, thrombopenia, anemia]
• general dullness, itch, nausea, vomiting, loss of appetite, tremor of hands like flapping, yellowing of white of the eyes and/or the skin, dark urine [liver failure, jaundice, hepatitis, liver dysfunction]
• headache, swollen face/eyelids, decreased urinary volume [renal disorder]
• loss of consciousness, dizziness, impaired judgment/mind, decreased/confused consciousness, headache, vomiting, paralysis on one side of the body, difficulty talking, decreased visual acuity, hyperventilation, tremor of the limbs [coma, cerebrovascular disease, brain edema]
• chills, sudden high fever with shivering, joint/muscle pain [sepsis]