Effects of this medicine

Before using this medicine, be sure to tell your doctor and pharmacist

• If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
  If you have difficulty in swallowing food or medicine.
  If you are unable to sit up for at least 30 minutes.
  If you are a patient with hypocalcemia.

• If you are pregnant or breastfeeding.

• If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

• Your dosing schedule prescribed by your doctor is <<        to be written by a healthcare professional>>

• In general, for adults, take 1 tablet (35mg of alendronate) at a time, with about 180mL of water, once weekly, first thing in the morning (before a meal). Strictly follow the instructions.
• You fix on the day of the week to take, please take on the morning of the same day of the week every week.
• Never take the medicine with other than water (e.g. mineral water of high calcium and magnesium content, tea, coffee, juice, milk, etc.). Never chew the medicine or dissolve it in a mouth.
• You should not drink and eat anything (except for water), and not take other medicine for 30 minutes after taking this medicine. You should not lay down for 30 minutes, and keep your body sitting up until you finish the first meal in a day. Do not take the medicine at bedtime or before rising.

• If you miss a dose, take 1 tablet on the next morning of the notice day (the dosage regimen is same as usual). And continue your regular dosing schedule (Morning on the specified day of the week) for next time. You should never take two doses at one time.

• If you accidentally take a dose for two days in a row or take double doses, you should do cessation of the medicine at the next scheduled day, you take a dose according to schedule after the next scheduled day. If you feel unusual, consult with your doctor or pharmacist.

• Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

• Keep the mouth clean.
• If you receive the dental treatment such as tooth extraction or implants, tell the dentist or oral surgeon about your taking this medicine.
• Try to ingest calcium through food.
• If you take supplements (e.g. calcium, vitamin D), check with your doctor or pharmacist in advance.

Possible adverse effects of this medicine

• difficulty in swallowing, swallowing pain, chest (back side of the bone) pain[esophageal disorder, intraoral disorder]
• epigastric pain, abdominal pain, abdominal discomfort[gastric disorder, duodenal disorder]
• fever, mucosal redness/erosion, erythema[toxic epidermal necrolysis, Stevens-Johnson syndrome]
• jaw pain/swelling/numbness, loose tooth, swelling of the gum[jaw bone necrosis, jaw osteomyelitis]
• the pain of the thigh or an inguinal region[atypical subtrochanteric and diaphyseal femoral fractures]

Storage conditions and other information

• Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
•  Do not store the remainder and consult your pharmacy or medical institution how to discard it.