Effects of this medicine

Before using this medicine, be sure to tell your doctor and pharmacist

• If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
  If you have bacterial/viral infection.
  If you have tuberculosis or have a history of it.
  If anyone who has close contact with you (anyone in your household, etc.) has tuberculosis.
  If you have interstitial pneumonia or have a history of it.
  If you have intestinal diverticulum.
  If you have leukopenia, neutropenia or thrombopenia.

• If you are pregnant or breastfeeding.

• If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

• Your dosing schedule prescribed by your doctor is <<        to be written by a healthcare professional>>

• In general, for adults, inject 1 syringe subcutaneously at a time, at an interval of 2 weeks. Strictly follow the instructions.
• Inject this medicine into the abdomen, thighs, or upper arms. Injection site should be rotated and changed every time you inject the medicine. Inject to the area at least 3 cm apart from the previously injected site. Avoid injecting this medicine into the skin with wound or rash.
• Blood test and/or ECG test may be performed before and during the treatment with this medicine.
• Only if you have received proper training at a medical facility and your doctor has judged you are capable of it, this medicine may be self-injected. Receive an explanation to fully understand how to self-inject and how to discard syringes and needles properly (used syringes and needles must never be re-used). Strictly follow the instructions.

• If you missed an injection, consult with your doctor. You should never inject two doses at one time.

• If you accidentally inject more than your prescribed dose, consult with your doctor or pharmacist.

• Do not stop injecting this medicine or not adjust the dosage unless your doctor instructs you to do so.

Precautions while taking this medicine

• You should receive blood test, chest X-ray test, and ECG test regularly during the treatment with this medicine. Receive these tests according to instructions of your doctor.

Possible adverse effects of this medicine

• lassitude, lightheadedness, decreased consciousness, impaired mind/judgment, glow, pale face, swelling around the eye/lip, hoarseness, breathlessness, shortness of breath, palpitation, urticaria[anaphylactic shock, anaphylactoid symptoms]
• cold-like symptoms, lassitude, fever, vomiting, shortness of breath, cough, sore throat, rash with pain, joint pain, pain on urination[infections]
• fever, dry cough, breathlessness, shortness of breath[interstitial pneumonia]
• nausea, vomiting, severe abdominal pain[intestinal perforation]
• fever, sore throat[agranulocytosis, leukopenia, neutropenia]
• nose/gum bleeding, continuous bleeding, blue spot, subcutaneous bleeding[thrombopenia]
• lassitude, body swelling, easy breathing in upright position than when lying down, breathlessness, shortness of breath, palpitation on exertion[cardiac failure]

Storage conditions and other information

• Keep out of the reach of children. Store in a box, keep in the refrigerator (2 to 8℃) to avoid light and freezing.
• Discard the remainder. Do not store them. Ask the pharmacist or healthcare facility how to discard them.
• If any symptoms suspected adverse reactions appear at the time of self-injection, consult with your doctor or pharmacist immediately.
  If you feel you are not able to continue self-injections, consult with your doctor immediately.
•  Do not receive live vaccines during the treatment with this medicine.