Effects of this medicine

Before using this medicine, tell your doctor/pharmacist

• If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
  If you have infection, tuberculosis, demyelinating disorders such as multiple sclerosis, optic nerve inflammation or its past history, congestive heart failure, blood disorders or its past history, a history of interstitial pneumonia, cancer or its past history.
  If you have received live vaccines (such as rubella/mumps vaccines) just before use of the medicine.

• If you are pregnant or breastfeeding.

• If you are using any other prescription or nonprescription (OTC) medicine. (It is important to reduce the risk of drug interactions.)

Dosage regimen (proper use of this medicine)

• Your dosage regimen is:(order of your doctor)

• General dosage regimen: For treatment of rheumatoid arthritis, for adults, dissolve 10 to 25 mg of the active ingredient into 1 mL of water for injection at a time and subcutaneously inject once a day on two different days (3 or 4 days apart) in the same week, or dissolve 25 to 50 mg into 1 mL of water for injection at a time and subcutaneously inject once a day, once a week.
  For treatment of active, polyarticular-course juvenile idiopathic arthritis, for children, inject subcutaneously 0.2 to 0.4 mg/kg of the active ingredient once a day on two different days (3 or 4 days apart) in the same week. Each dose for children should not exceed 25 mg.
  Strictly follow the instructions of your doctor/pharmacist in either case.
• Avoid injection to the site overlapped to previously injected sites (Inject the medicine at least 3 cm apart from the previous injected site).
• Do not massage the injected site after giving the injection.
• Patients can self-inject the medicine (self injection), only if the doctor has confirmed that patient meets certain criteria for the self-injection.

• Missed dose: If you missed an injection, check with your doctor/pharmacist or nurse.

• Overdose: If you used too much of the medicine (more than ordered), check with your doctor/pharmacist.

• Others: Do not stop your medication without the instructions of your doctor.

Precautions while using this medicine

• Do not receive live vaccines (such as rubella/mumps vaccines) because of infection risk of the virus. If you will receive live vaccines for prevention, inform your doctor that you are using the medicine and consult with him or her.

Side effects of this medicine

• sudden high fever with chill and trembling, blood pressure decrease[sepsis]
• persistent slight fever, persistent cough (for more than 2 weeks), dullness (general)[tuberculosis including extrapulmonary tuberculosis]
• fever, dullness (general), breathlessness[pneumonia, opportunistic infection]
• rash (general), swelling (general), breathlessness[serious allergic reactions]
• persistent fever, sore throat, paleness of the face [serious blood disorders]

Storage and other information

• Keep out of the reach of children. Store at 2-8℃ and avoid freezing.
• Discard the remainder. Do not store them. If you dispose of unused medicines, seek advice of your pharmacist about proper disposal of drugs.