Effects of this medicine

Before using this medicine, tell your doctor/pharmacist

• If you ever experienced any allergic reaction (itch, rash etc.) to any medicine. If you present a condition indicative of bone marrow suppression (including leucopenia). If you have diarrhea. If you have an infection. If you have hepatic dysfunction or a history of hepatic dysfunction. If you have renal dysfunction. If you have a heart disease or a history of heart disease. If you have gastrointestinal ulcers or hemorrhage. If you have diabetes or varicella. If you are having radiotherapy. If you have been previously treated with other chemotherapy medicines.

• If you are using TS-1, fluoropyrimidine anticancer drug, currently or within the last 7 days.

• If you are pregnant or breastfeeding.

• If you are using any other prescription or nonprescription (OTC) medicine. (It is important to reduce the risk of drug interactions.)

Dosage regimen (proper use of this medicine)

• Your dosage regimen is:(order of your doctor)

• General dosage regimen (for adults): UFT is administered 1-2 capsules (equivalent to 100-200mg of Tegafur) 3 times daily (at an interval of approximately 8 hours) together with 1 tablet (equivalent to 25mg of Calcium Folinate) of 25mg Uzel or 25mg Leucovorin. Administration should be withheld during one hour before or after meal. Repeat a course of 28 consecutive days (4 weeks) followed by a 7-day (1 week) rest period. Be sure to follow the dosage instructions.

• UFT must not be combined with TS-1, fluoropyrimidine anticancer drug. A minimum washout period of 7 days must be provided when UFT is used after withdrawal of TS-1.
• Meals affect the efficacy of Folinate plus Tegafur-Uracil combination therapy. Administration should be withheld during one hour before or after a meal.

• Missed dose: Proceed with the prescribed schedule of medication starting from the next dose. DO NOT take a double dose to make up for the missed dose.

• Overdose: If you took too much of this medicine (more than ordered), check with your doctor/pharmacist.

• Others: Do not stop taking medicine without the instructions of your doctor.

Precautions while using this medicine

• During the treatment, laboratory tests (hematological, liver and renal function tests) are performed regularly to detect asymptomatic side effects as early as possible. Be sure to consult your doctor.

Side effects of this medicine

• Bleeding tendency, tiredness, sore throat, fever[bone marrow suppression]
• Yellowing of the skin, tiredness, yellowing of the whites of the eyes, anorexia[severe hepatic dysfunction]
• Diarrhea, severe abdominal pain[severe enteritis]
• Unstableness, forgetfulness, trouble speaking[psychoneurologic disorders including leukoencephalopathy or other symptoms]
• Olfactory disturbance[anosmia]
• Difficult breathing, fever, dry cough[interstitial pneumonia]

Storage and other information

• Keep the medicine out of the reach of babies, infants and children. Store away from direct sunlight, heat, and humidity.
• If you have any left-over medicine, be sure to discard it. Check with the pharmacy regarding how to discard.