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See related Velcade powd for inj information |
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Manufacturer |
Janssen |
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Distributor |
Hong Kong: DKSH/Macau: Four Star |
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Contents |
Bortezomib |
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Indications |
Treatment of multiple myeloma & patient w/ mantle cell lymphoma who have received at least 1 prior therapy. |
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Dosage |
1.3 mg/m2/dose as a 3- to 5-sec bolus IV inj twice wkly for 2 wk (days 1, 4, 8 & 11) followed by a 10-day rest period (days 12-21). Treatment cycle: 3 wk. At least 72 hr should elapse between consecutive doses. Extended therapy of >8 cycles: Administered at standard schedule or on a maintenance schedule of once wkly for 4 wk (days 1, 8, 15 & 22) followed by a 13-day rest period (days 23-35). |
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Contraindications |
Hypersensitivity to bortezomib, boron or mannitol. |
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Special Precautions |
Peripheral neuropathy, orthostatic/postural hypotension, history of syncope, patient receiving drugs associated w/ hypotension, dehydrated patients. CHF may develop or exacerbate; monitor patients w/ risk factors for or existing heart disease. Monitor CBC, platelet count. Patients at risk for tumor lysis syndrome. Hepatic impairment. CrCl <13 mL/min & patients on hemodialysis. Pregnancy & lactation. |
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Adverse Drug Reactions |
Fatigue, malaise & weakness, nausea, diarrhea, decreased appetite (including anorexia), constipation, thrombocytopenia, peripheral neuropathy (including peripheral sensory neuropathy & aggravated peripheral neuropathy), pyrexia, vomiting, anemia, neutropenia.
View ADR Monitoring Form |
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Drug Interactions |
Cytochrome P4503A4 inhibitors or inducers. Oral antidiabetic agents. Drugs associated w/ peripheral neuropathy (eg amiodarone, antivirals, INH, nitrofurantoin or statins) or w/ a decrease in BP.
View more drug interactions with Velcade |
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Pregnancy Category (US FDA) |
Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective). |
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Presentation/Packing |
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Form |
Packing |
Photo |
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Velcade powder for injection |
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Velcade (single-use) 3.5 mg x 1's |
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Manufacturer: |
Janssen |
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Distributor: |
Hong Kong: DKSH
Macau: Four Star |
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