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See related Afinitor tab information |
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Manufacturer |
Novartis |
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Distributor |
Hong Kong: Zuellig/Macau: Four Star |
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Contents |
Everolimus |
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Indications |
Treatment of advanced renal cell carcinoma which has progressed on or after treatment w/ VEGF-targeted therapy.
Click to view Afinitor detailed prescribing infomation |
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Dosage |
10 mg once daily.
Click to view Afinitor detailed prescribing infomation |
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Overdosage |
View Afinitor overdosage for action to be taken in the event of an overdose. |
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Administration |
May be taken with or without food (Take consistently either always w/ or always w/o meals. Swallow whole, do not chew/crush. Avoid grapefruit juice.). |
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Contraindications |
Hypersensitivity to rapamycin derivatives. Severe hepatic impairment (Child-Pugh class C), galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption.
Click to view Afinitor detailed prescribing infomation |
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Special Precautions |
New or worsening resp symptoms. Treat preexisting infection prior to treatment. Monitor renal function, fasting serum glucose level, complete blood count. Peri-surgical period. May affect ability to drive or operate machinery. Childn <18 yr. Pregnancy & lactation.
Click to view Afinitor detailed prescribing infomation |
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Adverse Drug Reactions |
Infections; blood count, glucose, cholesterol, triglycerides or liver function test abnormalities; anorexia, abnormal taste, pneumonitis, dyspnoea, epistaxis, cough, stomatitis, diarrhoea, mucosal inflammation, vomiting, nausea, rash, dry skin, pruritus, fatigue, asthenia, peripheral oedema.
View ADR Monitoring Form |
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Drug Interactions |
Ketoconazole, itraconazole, posaonazole, voriconazole, telithromycin, clarithromycin, nefazodone, ritonavir, atazanavir, saquinavir, darunavir, indinavir, nelfinavir. Rifampicin, carbamazepine, phenobarb, phenytoin, efavirenz, nevirapine. Erythromycin, verapamil, oral ciclosporin, fluconazole, diltiazem, amprenavir, fosamprenavir. Avoid use of live vaccines, St. John's wort & grapefruit juice.
View more drug interactions with Afinitor |
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Pregnancy Category (US FDA) |
Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective). |
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Description |
View Afinitor description for details of the chemical structure and excipients (inactive components). |
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Mechanism of Action |
View Afinitor mechanism of action for pharmacodynamics and pharmacokinetics details. |
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