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See related Crestor film-coated tab information |
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Manufacturer |
AstraZeneca |
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Distributor |
Hong Kong: Zuellig/Macau: Four Star |
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Contents |
Rosuvastatin Ca |
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Indications |
Adjunct to diet to reduce elevated total-cholesterol, LDL-cholesterol, apolipoprotein B, nonHDL-cholesterol & triglycerides levels & to increase HDL-cholesterol in patients w/ primary hyperlipidemia & mixed dyslipidemia; adjunct to diet to reduce total-cholesterol, LDL-cholesterol & apolipoprotein B levels in childn 10-17 yr w/ heterozygous familial hypercholesterolemia (HeFH) (LDL-cholesterol >190 or >160 mg/dL); +ve family history of premature cardiovascular disease (CVD) or ≥2 other CVD risk factors. Adjunct to diet in patients w/ hyperglyceridemia & primary dysbetalipoproteinemia. Patients w/ homozygous familial hypercholesterolemia to reduce LDL-cholesterol, total-cholesterol & apolipoprotein B. Adjunct to diet in slowing atherosclerosis progression as part of treatment strategy to lower total-cholesterol and LDL-cholesterol. Primary prevention of CVD to reduce risk of stroke, MI & arterial revascularization in patients w/o clinically evident CHD but w/ increased risk of CVD based on ≥50 yr in men & ≥60 yr in women, hsCRP ≥2 mg/L & the presence of at least 1 additional CVD risk factor eg HTN, low HDL-cholesterol, smoking, family history of premature CHD.
Click to view Crestor detailed prescribing infomation |
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Dosage |
Usual initial dose: 10-20 mg once daily. Patients not reaching LDL-C goal w/ 20 mg: 40 mg. Childn & adolescent 10-17 yr HeFH 5-20 mg/day. Max: 20 mg/day. Homozygous familial hypercholesterolemia Initially 20 mg. Patients taking cyclosporine Max: 5 mg once daily. Patients taking lopinavir & ritonavir or atazanavir & ritonavir Max: 10 mg once daily. Asians & patients w/ severe renal insufficiency Initially 5 mg once daily.
Click to view Crestor detailed prescribing infomation |
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Overdosage |
View Crestor overdosage for action to be taken in the event of an overdose. |
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Administration |
May be taken with or without food |
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Contraindications |
Active liver disease or w/ unexplained persistent elevations of serum transaminases. Pregnancy & lactation.
Click to view Crestor detailed prescribing infomation |
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Warnings |
For additional cautionary notes to warn of the potential risk of using the medicine... click to view Crestor detailed prescribing infomation |
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Special Precautions |
Skeletal muscle effects, liver enzyme abnormalities & monitoring, concomitant therapy w/ coumarin anticoagulants, proteinuria & hematuria, endocrine effects.
Click to view Crestor detailed prescribing infomation |
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Adverse Drug Reactions |
Headache, myalgia, abdominal pain, asthenia, nausea.
View ADR Monitoring Form |
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Side Effects |
View Crestor side effects |
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Drug Interactions |
Cyclosporine, gemfibrozil, lopinavir/ritonavir or atazanavir/ritonavir, coumarin anticoagulants, niacin, fenofibrate, antacids, ketoconazole, itraconazole.
View more drug interactions with Crestor |
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Pregnancy Category (US FDA) |
Category X: Studies in animals or human beings have demonstrated foetal abnormalities or there is evidence of foetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant. |
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Caution For Usage |
For caution against possible variation of physical aspect of medicine... click to view Crestor detailed prescribing infomation |
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Storage |
View Crestor storage conditions for details to ensure optimal shelf-life. |
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Description |
View Crestor description for details of the chemical structure and excipients (inactive components). |
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Mechanism of Action |
View Crestor mechanism of action for pharmacodynamics and pharmacokinetics details. |
