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Manufacturer Pfizer 
Distributor Hong Kong: Zuellig/Macau: The Glory Medicina 
Contents Sunitinib malate
Indications Treatment of GI stromal tumor after disease progression on or intolerance to imatinib mesylate; advanced renal cell carcinoma; progressive, well-differentiated pancreatic neuroendocrine tumor in patient w/ unresectable locally advanced or metastatic disease.
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Dosage GI stromal tumor & renal cell carcinoma 50 mg daily over 4 wk, followed by a 2-wk off. Pancreatic neuroendocrine tumor 37.5 mg daily continuously w/o a scheduled off-treatment period. Max: 50 mg daily. Dose modification of 12.5-mg increment is based on individual safety & tolerability.
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Overdosage View Sutent overdosage for action to be taken in the event of an overdose.
Administration May be taken with or without food
Special Precautions Baseline periodic monitoring of liver function tests, left ventricular ejection fraction & clinical signs & symptoms of CHF. Left ventricular dysfunction. QT interval prolongation, torsade de pointes, HTN, hemorrhagic events, thyroid dysfunction, impaired wound healing, adrenal insufficiency. Perform CBC w/ platelet count & serum chemistries including phosphate at the beginning of each treatment cycle. Pregnancy & lactation. Elderly. Childn.
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Adverse Drug Reactions Fatigue, asthenia, fever, diarrhea, nausea, mucositis/stomatitis, vomiting, dyspepsia, abdominal pain, constipation, HTN, peripheral edema, rash, hand-foot syndrome, skin discoloration, dry skin, hair color changes, altered taste, headache, back pain, arthralgia, pain in extremities, cough, dyspnea, anorexia & bleeding.
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Drug Interactions CYP3A4 inhibitors eg ketoconazole, itraconazole, clarithromycin, atazanavir, indinavir, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, voriconazole, grapefruit juice; CYP3A4 inducers eg rifampin, dexamethasone, phenytoin, carbamazepine, rifabutin, rifapentin, phenobarb, St. John's wort.
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Pregnancy Category (US FDA)      
     
Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective). 
Description View Sutent description for details of the chemical structure and excipients (inactive components).
Mechanism of Action View Sutent mechanism of action for pharmacodynamics and pharmacokinetics details.

Presentation/Packing
Form Packing Photo
Sutent capsule  Sutent 12.5 mg x 28's 
Sutent 50 mg x 28's 
 
Manufacturer: Pfizer
 
Distributor: Hong Kong: Zuellig
Macau: The Glory Medicina