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See related Maxipime powd for inj information |
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Manufacturer |
Bristol-Myers Squibb |
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Distributor |
Hong Kong: DKSH/Macau: Four Star |
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Contents |
Cefepime HCl |
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Indications |
Adult only Lower resp tract, intra-abdominal, biliary tract & gynaecological infections, septicaemia. Surgical prophylaxis in intra-abdominal surgery. Paed only Pneumonia & bacterial meningitis. Adult & paed Pneumonia, complicated & uncomplicated urinary tract, biliary tract & skin & skin structure infections, empiric treatment in febrile neutropenia.
Click to view Maxipime detailed prescribing infomation |
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Dosage |
Adult & childn > 40 kg Mild to moderate UTI 0.5-1 g IM/IV 12 hrly. Mild to moderate infections other than UTI 1g IM/IV 12 hrly. Severe infections 2 g IV 12 hrly. Very severe or life-threatening infections 2 g IV 8 hrly. Surgical prophylaxis 2 g as a single IV infusion dose starting 60 min pre-op. Administer a single metronidazole 500 mg IV dose immediately following completion of the Maxipime infusion. If surgical procedure lasts >12 hr from initial prophylactic dose, administer a 2nd dose of Maxipime followed by metronidazole 12 hr after the initial prophylactic dose. Childn >2 mth & ≤40 kg Pneumonia, UTI, skin & skin structure infection 50 mg/kg 12 hrly for 10 days. More severe infections 50 mg/kg 8 hrly for 10 days. Bacterial meningitis & empiric treatment of febrile neutropenia 50 mg/kg 8 hrly for 7-10 days. Childn >40 kg Adult dose. Max: 2 g 8 hrly.
Click to view Maxipime detailed prescribing infomation |
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Overdosage |
View Maxipime overdosage for action to be taken in the event of an overdose. |
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Contraindications |
Hypersensitivity to cephalosporins, penicillins or other β-lactam antibiotics.
Click to view Maxipime detailed prescribing infomation |
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Warnings |
For additional cautionary notes to warn of the potential risk of using the medicine... click to view Maxipime detailed prescribing infomation |
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Special Precautions |
Hypersensitivity, pseudomembranous colitis & superinfection may occur. Renal impairment. Patient who develops diarrhea. Discontinue therapy if allergic reaction occurs. Concurrent treatment w/ nephrotoxic drugs eg aminoglycosides & potent diuretics. Pregnancy & lactation. Elderly.
Click to view Maxipime detailed prescribing infomation |
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Adverse Drug Reactions |
Rash, pruritus, urticaria; nausea, vomiting, oral moniliasis, diarrhea; pseudomembranous colitis; headache; fever, vaginitis, erythema, inj site reactions. Elevations in ALT & AST, alkaline phosphatase, total bilirubin, anemia, eosinophilia, prolonged prothrombin time, partial thromboplastin time. +ve Coombs' test w/o hemolysis. Transient elevations of BUN &/or serum creatinine & transient thrombocytopenia, leukopenia & neutropenia.
View ADR Monitoring Form |
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Drug Interactions |
Aminoglycosides, frusemide & other nephrotoxic drugs.
View more drug interactions with Maxipime |
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Pregnancy Category (US FDA) |
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters). |
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Caution For Usage |
For caution against possible variation of physical aspect of medicine... click to view Maxipime detailed prescribing infomation |
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Storage |
View Maxipime storage conditions for details to ensure optimal shelf-life. |
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Description |
View Maxipime description for details of the chemical structure and excipients (inactive components). |
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Mechanism of Action |
View Maxipime mechanism of action for pharmacodynamics and pharmacokinetics details. |
