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See related Certican tab information |
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Manufacturer |
Novartis |
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Distributor |
Hong Kong: Zuellig/Macau: Four Star |
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Contents |
Everolimus |
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Indications |
In combination w/ ciclosporin (for microemulsion) & corticosteroids. Prophylaxis of organ rejection in adults at low to moderate immunological risk receiving renal or cardiac transplant.
Click to view Certican detailed prescribing infomation |
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Dosage |
Adult Initially 0.75 mg bd administered after transplantation. Adjust dose at 4-5 days intervals based on achieved blood levels, tolerability, response, change in co-medications & clinical situation.
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Overdosage |
View Certican overdosage for action to be taken in the event of an overdose. |
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Administration |
May be taken with or without food (Take consistently either always w/ or always w/o meals. Avoid grapefruit juice.). |
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Contraindications |
[Click for Certican detailed prescribing infomation] |
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Special Precautions |
Hepatic impairment. Monitor patients for skin neoplasms; minimise exposure to UV light & sunlight. Increased susceptibility to infections. Established hyperlipidemia. Monitor renal function. Pregnancy & lactation.
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Adverse Drug Reactions |
Viral, bacterial & fungal infections, sepsis, leucopenia & other hematological disorders, hypercholesterolaemia, hyperlipidemia, hypertriglyceridaemia, HTN, lymphocoele, VTE, pneumonia, GI disturbances, acne, surgical wound complication, UTI, oedema, pain.
View ADR Monitoring Form |
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Drug Interactions |
Strong & moderate CYP3A4 inhibitors/inducers, ciclosporin, rifampicin, fluconazole, macrolides, Ca-channel blockers, PIs, St. John's wort, anticonvulsants, anti-HIV drugs, grapefruit juice, live vaccines.
View more drug interactions with Certican |
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Pregnancy Category (US FDA) |
Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective). |
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Caution For Usage |
For caution against possible variation of physical aspect of medicine... click to view Certican detailed prescribing infomation |
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Storage |
View Certican storage conditions for details to ensure optimal shelf-life. |
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Description |
View Certican description for details of the chemical structure and excipients (inactive components). |
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Mechanism of Action |
View Certican mechanism of action for pharmacodynamics and pharmacokinetics details. |
