See related Janumet information 
 
Manufacturer MSD 
Distributor Hong Kong: DKSH/Macau: Four Star 
Contents Per 50/500 mg tab Sitagliptin 50 mg, metformin HCl 500 mg. Per 50/1000 mg tab Sitagliptin 50 mg, metformin HCl 1,000 mg
Indications Adjunct to diet & exercise to improve glycemic control in adult w/ type 2 DM when treatment w/ both sitagliptin & metformin is appropriate.
Click to view Janumet detailed prescribing infomation
Dosage Individualised dosage not exceeding max daily dose of 100 mg sitagliptin & 2,000 mg metformin. Generally given bd. Patients inadequately controlled on metformin alone Usual starting dose: Sitagliptin 50 mg bd, plus the dose of metformin already being taken. For patients taking metformin 850 mg bd, the recommended starting dose is 50 mg sitagliptin/1,000 mg metformin HCl bd. Patients inadequately controlled on sitagliptin alone Usual starting dose: 50 mg sitagliptin/500 mg metformin HCl bd. Dose may be titrated up to 50 mg sitagliptin/1,000 mg metformin HCl bd. Switching from co-administration of sitagliptin & metformin May be initiated at the dose of sitagliptin & metformin already being taken.
Click to view Janumet detailed prescribing infomation
Overdosage View Janumet overdosage for action to be taken in the event of an overdose.
Administration Should be taken with food
Contraindications Renal disease or renal dysfunction (serum creatinine levels ≥1.5 mg/dL for males, ≥1.4 mg/dL for females or abnormal CrCl) which may also result from conditions eg CV collapse (shock), acute MI & septicemia. Acute or chronic metabolic acidosis, including diabetic ketoacidosis, w/ or w/o coma. Temporarily discontinue in radiologic studies involving intravascular administration of iodinated contrast materials. Type 1 diabetes. Lactation.
Click to view Janumet detailed prescribing infomation
Special Precautions Monitor renal function. Debilitated, malnourished patients & w/ adrenal or pituitary insufficiency or alcohol intoxication in which patients are susceptible to hypoglycaemia. Hypoglycaemia (in combination w/ a sulfonylurea or insulin), lactic acidosis, hypoxic states, surgery, impaired hepatic function, decreased vit B12 absorption. Pregnancy. Elderly.
Click to view Janumet detailed prescribing infomation
Adverse Drug Reactions Diarrhea, nausea, dyspepsia, flatulence, vomiting, abdominal discomfort, indigestion, asthenia, headache, hypoglycaemia, nasopharyngitis, fungal skin infection, peripheral edema. Hypersensitivity reaction. Pancreatitis, worsening of renal function, constipation, upper resp tract infection.
View ADR Monitoring Form
Side Effects View Janumet side effects
Drug Interactions Alcohol intake. Sitagliptin: Digoxin, cyclosporin. Metformin: Furosemide, nifedipine, cationic drugs (eg amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim or vancomycin), cimetidine. Drugs producing hyperglycaemia eg thiazides & other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, OC, phenytoin, nicotinic acid, sympathomimetics, Ca channel blockers & INH.
View more drug interactions with Janumet
Pregnancy Category (US FDA)      
     
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters). 
Description View Janumet description for details of the chemical structure and excipients (inactive components).
Mechanism of Action View Janumet mechanism of action for pharmacodynamics and pharmacokinetics details.

Presentation/Packing
Form Packing Photo

Janumet 50/500 mg film-coated tablet  Janumet 56's 
 
Janumet 50/1000 mg film-coated tablet  Janumet 56's
 

 
Manufacturer: MSD
 
Distributor: Hong Kong: DKSH