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See related Octostim inj information |
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Manufacturer |
Ferring |
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Distributor |
Hong Kong: Ferring |
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Contents |
Desmopressin acetate |
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Indications |
Shortening or normalization of prolonged bleeding time prior to an invasive operation; prolonged bleeding time as a consequence of congenital or drug-induced thrombocyte dysfunction, uraemia, cirrhosis of the liver or unknown aetiology. Therapeutic control of bleeding & bleeding prophylaxis in patients w/ haemophilia A & von Willebrand's disease.
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Dosage |
0.3 mcg/kg SC or IV infusion over 15-30 min. If a positive effect is obtained, the initial dose may be repeated 1-2 times w/ intervals of 6-12 hr.
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Contraindications |
Habitual or psychogenic polydipsia; unstable angina pectoris; decompensated cardiac insufficiency; von Willebrand's disease type IIB.
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Special Precautions |
Avoid fluid overload & hyponatremia in the very young & elderly patient, conditions characterized by fluid &/or electrolyte imbalance, patient at risk of increased intracranial pressure & those requiring diuretic treatment.
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Adverse Drug Reactions |
Fatigue, headache, nausea & stomach pain. At the time of administration, transient fall in BP w/ reflex tachycardia & facial flushing. Rarely, dizziness.
View ADR Monitoring Form |
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Side Effects |
View Octostim side effects |
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Drug Interactions |
Indomethacin may augment the magnitude but not the duration of the response to desmopressin.
View more drug interactions with Octostim |
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Pregnancy Category (US FDA) |
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters). |
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Storage |
View Octostim storage conditions for details to ensure optimal shelf-life. |
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Description |
View Octostim description for details of the chemical structure and excipients (inactive components). |
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Mechanism of Action |
View Octostim mechanism of action for pharmacodynamics and pharmacokinetics details. |
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ATC Classification |
H01BA02 - desmopressin ; Belongs to the class of vasopressin and analogues. Used in posterior pituitary lobe hormone preparations. |
