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See related Aldurazyme infusion information |
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Manufacturer |
Genzyme |
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Distributor |
Hong Kong: DKSH |
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Contents |
Laronidase |
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Indications |
Hurler & Hurler-Scheie forms of mucopolysaccharidosis I & Scheie form w/ moderate to severe symptoms. |
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Dosage |
Recommended dose: 0.58 mg/kg body wt IV once wkly. Infusion rate: Initially 10 mcg/kg/hr, may be increased every 15 min during the 1st hr until max of 200 mcg/kg/hr for 2-3 hr. Patient >20 kg body wt Total vol: 250 mL. ≤20 kg body wt Total vol: 100 mL. |
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Special Precautions |
Patients should receive antipyretics &/or antihistamines prior to infusion. Pregnancy & lactation. |
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Adverse Drug Reactions |
Anaphylactic reaction (urticaria, airway obstruction), upper resp tract infection, rash & inj-site reaction, infusion-related reactions esp flushing.
View ADR Monitoring Form |
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Pregnancy Category (US FDA) |
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters). |
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ATC Classification |
A16AB05 - laronidase ; Belongs to the class of enzymes. Used in treatment of alimentary tract and metabolism problems. |
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Presentation/Packing |
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Form |
Packing |
Photo |
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Aldurazyme infusion |
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Aldurazyme 2.9 mg/5 mL x 1's |
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Manufacturer: |
Genzyme |
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Distributor: |
Hong Kong: DKSH
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