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See related Revatio film-coated tab information |
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Manufacturer |
Pfizer |
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Distributor |
Hong Kong: Zuellig |
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Contents |
Sildenafil citrate |
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Indications |
Class III pulmonary arterial HTN.
Click to view Revatio detailed prescribing infomation |
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Dosage |
Adult ≥18 yr 20 mg tds. Renal (CrCl <30 mL/min)/hepatic impairment (Child-Pugh A & B) Downward dose adjustment to 20 mg bd.
Click to view Revatio detailed prescribing infomation |
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Overdosage |
View Revatio overdosage for action to be taken in the event of an overdose. |
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Administration |
May be taken with or without food |
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Contraindications |
Co-administration w/ nitric oxide donors or nitrates in any form. Combination w/ ketoconazole, itraconazole, ritonavir. Severe hepatic impairment, recent history of stroke or MI, severe hypotension (BP <90/50 mmHg) at initiation. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption.
Click to view Revatio detailed prescribing infomation |
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Special Precautions |
Severe pulmonary arterial HTN (class IV); patient at risk of non-arteritic anterior ischemic optic neuropathy (NAION); known hereditary degenerative retinal disorders eg retinitis pigmentosa; hypotension; fluid depletion; severe left ventricular outflow obstruction or autonomic dysfunction; anatomical deformation of the penis; conditions predisposing to priapism; bleeding disorders or active peptic ulceration. May impair ability to drive or operate machinery. Pregnancy & lactation. Childn & adolescents <18 yr.
Click to view Revatio detailed prescribing infomation |
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Adverse Drug Reactions |
Headache, flushing, diarrhoea, dyspepsia, limb pain.
View ADR Monitoring Form |
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Drug Interactions |
β-blockers, ketoconazole, itraconazole, ritonavir, saquinavir, erythromycin, carbamazepine, phenytoin, phenobarb, St. John's wort, rifampicin, cimetidine, grapefruit juice, nicorandil, bosentan, amlodipine, α-blockers. Potentiates hypotensive effect of nitrates.
View more drug interactions with Revatio |
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Pregnancy Category (US FDA) |
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters). |
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Mechanism of Action |
View Revatio mechanism of action for pharmacodynamics and pharmacokinetics details. |
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ATC Classification |
G04BE03 - sildenafil ; Belongs to the class of drugs used in erectile dysfunction. |
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Presentation/Packing |
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Form |
Packing |
Photo |
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Revatio film-coated tablet |
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Manufacturer: |
Pfizer |
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Distributor: |
Hong Kong: Zuellig |
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