Multaq / 心韻定 - Hong Kong[香港药品]

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Multaq / 心韻定

2014-03-01 14:36:17 来源: 作者: 【大中小】浏览:664次评论:0条

See related Multaq film-coated tab information

Manufacturer

sanofi-aventis

Distributor

Hong Kong: LF Asia

Contents

Dronedarone HCl

Indications

History of, or current atrial fibrillation to reduce risk of CV hospitalization.
Click to view Multaq detailed prescribing infomation

Dosage

Adult 400 mg bd.
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Overdosage

View Multaq overdosage for action to be taken in the event of an overdose.

Administration

Should be taken with food (Avoid grapefuit juice.).

Contraindications

Severe CHF (NYHA stage IV) & other unstable hemodynamic conditions; 2nd- or 3rd-degree AV block or sick sinus syndrome (except when used in conjunction w/ a functioning pacemaker); bradycardia <50 bpm; co-administration w/ strong CYP3A4 inhibitors eg ketoconazole, itraconazole, voriconazole, cyclosporin, telithromycin, clarithromycin, nefazodone & ritonavir; co-administration w/ torsades de pointes inducers eg phenothiazines, TCAs, certain oral macrolides, class I & III antiarrhythmics; QTc Bazett interval ≥500 msec; severe hepatic impairment. Pregnancy & lactation.
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Special Precautions

May induce QTc Bazett prolongation. Patients w/ moderate CHF (NYHA stage III). Discontinue if heart failure develops or worsens. Liver function tests should be obtained prior to treatment & monitor thereafter. Correct K or Mg deficiency before & during therapy. Monitor plasma creatinine. Childn <18 yr.
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Adverse Drug Reactions

CHF, diarrhoea, nausea, vomiting, fatigue, asthenia, abdominal pain, dyspepsia, bradycardia, rashes, pruritis.
View ADR Monitoring Form

Drug Interactions

β-blockers, Ca antagonists, digoxin; phenothiazines, bepridil, TCAs, certain oral macrolides, class I & III antiarrhythmics; doxorubicin, fexofenadine, talinolol; rifampicin, phenobarb, carbamazepine, phenytoin; ketoconazole, itraconazole, voriconazole, ritonavir, cyclosporin, telithromycin, clarithromycin, erythromycin; sirolimus & tacrolimus; simvastatin, lovastatin, atorvastatin, pravastatin; theophylline; warfarin, grapefruit juice, St. John's wort.
View more drug interactions with Multaq

Pregnancy Category (US FDA)

Category X: Studies in animals or human beings have demonstrated foetal abnormalities or there is evidence of foetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.

Storage

View Multaq storage conditions for details to ensure optimal shelf-life.

Description

View Multaq description for details of the chemical structure and excipients (inactive components).

Mechanism of Action

View Multaq mechanism of action for pharmacodynamics and pharmacokinetics details.

ATC Classification

C01BD07 - dronedarone ;

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