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See related Zoladex information |
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Manufacturer |
AstraZeneca |
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Distributor |
Hong Kong: Zuellig/Macau: Four Star |
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Contents |
Goserelin acetate |
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Indications |
Zoladex/Zoladex LA Prostate cancer for hormonal manipulation. Zoladex Advanced breast cancer for hormonal manipulation & alternative to chemotherapy in pre-menopausal & perimenopausal estrogen receptor (ER) positive early breast cancer. Endometriosis, endometrial thinning, uterine fibroids, assisted reproduction.
Click to view Zoladex detailed prescribing infomation |
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Dosage |
Zoladex Adult 1 depot SC inj into the anterior abdominal wall every 28 days. Endometriosis Max: 6 mth. Endometrial thinning 2 depots administered 4 wk apart, w/ surgery timed between 0 & 2 wk after 2nd depot. Uterine fibroids 1 depot w/ supplementary iron for up to 3 mth pre-op. Zoladex LA 1 depot SC inj into the anterior abdominal wall every 12 wk.
Click to view Zoladex detailed prescribing infomation |
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Overdosage |
View Zoladex overdosage for action to be taken in the event of an overdose. |
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Contraindications |
Hypersensitivity to goserelin acetate or to other LHRH analogues. Pregnancy & lactation. Childn. Zoladex LA Female.
Click to view Zoladex detailed prescribing infomation |
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Special Precautions |
Zoladex/Zoladex LA Ureteric obstruction or spinal cord compression. Zoladex Reduced bone mineral density. Male Reduced glucose tolerance, increased risk of developing MI, sudden cardiac death & stroke. Female Metabolic bone disease, uterine cervical resistance, risk of developing ovarian hyperstimulation syndrome (OHSS). Polycystic ovarian syndrome.
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Adverse Drug Reactions |
Decreased libido, hot flushes, hyperhidrosis, paraesthesia, abnormal BP, rash, inj site reactions, decreased bone density. Male Erectile dysfunction, impaired glucose tolerance, spinal cord compression, cardiac failure, MI, temporary increase in bone pain, gynaecomastia. Female Vulvovaginal dryness, breast enlargement, altered mood & depression, headache, arthralgia, tumour flare & pain.
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Drug Interactions |
[Click for Zoladex detailed prescribing infomation]
View more drug interactions with Zoladex |
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Pregnancy Category (US FDA) |
Category X: Studies in animals or human beings have demonstrated foetal abnormalities or there is evidence of foetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant. |
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Caution For Usage |
For caution against possible variation of physical aspect of medicine... click to view Zoladex detailed prescribing infomation |
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Storage |
View Zoladex storage conditions for details to ensure optimal shelf-life. |
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Mechanism of Action |
View Zoladex mechanism of action for pharmacodynamics and pharmacokinetics details. |
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Presentation/Packing |
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Form |
Packing |
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Zoladex SafeSystem depot injection |
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Zoladex 3.6 mg x 1's |
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Zoladex LA SafeSystem depot injection |
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Zoladex LA 10.8 mg x 1's |
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Manufacturer: |
AstraZeneca |
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Distributor: |
Hong Kong: Zuellig
Macau: Four Star
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