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See related Humira inj information |
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Manufacturer |
Abbott |
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Distributor |
Hong Kong: Zuellig/Macau: The Glory Medicina |
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Contents |
Adalimumab |
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Indications |
Monotherapy or in combination w/ methotrexate (MTX) for treatment of moderate to severe, active RA in adults when response to disease-modifying antirheumatic drugs (DMARDs) including MTX has been inadequate; treatment of severe, active & progressive RA in adults not previously treated w/ MTX. Reduction of progression rate of joint damage to improve physical function. Treatment of active polyarticular juvenile idiopathic arthritis in adolescents 13-17 yr who have inadequate response to ≥1 DMARDs. Treatment of active & progressive psoriatic arthritis in adults when response to previous DMARD therapy has been inadequate. Treatment of adults w/ severe, active ankylosing spondylitis who have had an inadequate response to conventional therapy. Treatment of severe, active Crohn's disease in patients who have not responded despite full & adequate therapy w/ corticosteroid &/or immunosuppressant or w/ intolerance or medical CI for such therapies. Treatment of moderate to severe chronic plaque psoriasis in adults who failed to respond, contraindicated or intolerant to other systemic therapy w/ cyclosporine, MTX or PUVA.
Click to view Humira detailed prescribing infomation |
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Dosage |
Adult RA 40 mg SC as a single dose every other wk. MTX should be continued during treatment w/ Humira. In monotherapy, patient who experience decrease in response may benefit from an increase in dose intensity to 40 mg every wk. Psoriatic arthritis & ankylosing spondylitis 40 mg SC as a single dose every other wk. Crohn's disease 80 mg at wk 0, followed by 40 mg at wk 2 as induction regimen, then 40 mg SC every other wk thereafter. Psoriasis Initially 80 mg SC, followed by 40 mg SC given every other wk starting 1 wk after the initial dose. Polyarticular juvenile idiopathic arthritis Adolescent & childn 13-17 yr 40 mg SC as a single dose every other wk.
Click to view Humira detailed prescribing infomation |
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Overdosage |
View Humira overdosage for action to be taken in the event of an overdose. |
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Contraindications |
[Click for Humira detailed prescribing infomation] |
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Special Precautions |
Active infections including chronic or localized infections; history of recurring infection or w/ underlying condition predisposing to infection; carriers of HBV as reactivation may occur; preexisting or recent-onset CNS demyelinating disorders; history of lymphoma or malignancy; serious allergic reactions; eva luate active or latent TB infection before initiation of therapy; discontinue in case of confirmed significant hematologic abnormalities; development of blood dyscrasias; worsening of CHF, discontinue if symptoms of lupus-like syndrome develops. Women of childbearing potential. Pregnancy & lactation. Elderly >65 yr. Childn <4 yr & <15 kg.
Click to view Humira detailed prescribing infomation |
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Adverse Drug Reactions |
Resp tract infections, leucopenia, anemia, increased lipids, headache, abdominal pain, nausea & vomiting, elevated liver enzymes, rash, musculoskeletal pain, inj site reaction.
View ADR Monitoring Form |
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Drug Interactions |
Avoid administration w/ anakinra, abatacept, live vaccines.
View more drug interactions with Humira |
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Pregnancy Category (US FDA) |
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters). |
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Storage |
View Humira storage conditions for details to ensure optimal shelf-life. |
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Description |
View Humira description for details of the chemical structure and excipients (inactive components). |
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Mechanism of Action |
View Humira mechanism of action for pharmacodynamics and pharmacokinetics details. |
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Presentation/Packing |
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Form |
Packing |
Photo |
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Humira injection |
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Humira (ready-to-use) 40 mg/0.8 mL x 2's |
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Manufacturer: |
Abbott |
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Distributor: |
Hong Kong: Zuellig
Macau: The Glory Medicina |
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