Call your doctor right away if you have any of the following symptoms of infection:
Fever or chills
Skin that looks red or swollen and is hot or tender to touch
Severe abdominal pain
Frequent or urgent need to urinate or burning feeling when you urinate
Skin problems.
Skin problems such as inflammation of your skin (dermatitis), rash, and eczema may happen if you take Prolia. Call your doctor if you have any of the following symptoms of skin problems that do not go away or get worse:
Redness
Itching
Small bumps or patches (rash)
Your skin is dry or feels like leather
Blisters that ooze or become crusty
Skin peeling
Severe jaw bone problems (osteonecrosis).
Severe jaw bone problems may happen when you take Prolia. Your doctor should examine your mouth before you start Prolia. Your doctor may tell you to see your dentist before you start Prolia. It is important for you to practice good mouth care during treatment with Prolia.
Call your doctor right away if you have any of these side effects.

What is Prolia?

Prolia is a prescription medicine used to treat osteoporosis (thinning and weakening of bone) in women after menopause (“change of life”) who

Have an increased risk for fractures (broken bones).
Cannot use another osteoporosis medicine or other osteoporosis medicines did not work well.
Who should not receive Prolia?

Do not take Prolia if you have been told by your doctor that your blood calcium level is too low.

What should I tell my doctor before receiving Prolia?

Before taking Prolia, tell your doctor if you:

Have low blood calcium.
Cannot take daily calcium and vitamin D.
Had parathyroid or thyroid surgery (glands located in your neck).
Have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome).
Have kidney problems or are on kidney dialysis.
Plan to have dental surgery or teeth removed.
Are pregnant or plan to become pregnant. Prolia may harm your unborn baby. Tell your doctor right away if you become pregnant while taking Prolia.
Pregnancy Surveillance Program: Prolia is not intended for use in pregnant women. If you become pregnant while taking Prolia, talk to your doctor about enrolling with Amgen’s Pregnancy Surveillance Program or call 1-800-772-6436 (l-800-77-AMGEN). The purpose of this program is to collect information about women who have become pregnant while taking Prolia.

Are breast-feeding or plan to breast-feed. It is not known if Prolia passes into your breast milk. You and your doctor should decide if you will take Prolia or breast-feed. You should not do both.
Tell your doctor about all the medicines you take, including prescription and nonprescription drugs, vitamins, and herbal supplements.

Know the medicines you take. Keep a list of medicines with you to show to your doctor or pharmacist when you get a new medicine.

How will I receive Prolia?

Prolia is an injection that will be given to you by a healthcare professional. Prolia is injected under your skin (subcutaneous).
You will receive Prolia 1 time every 6 months.
You should take calcium and vitamin D as your doctor tells you to while you receive Prolia.
If you miss a dose of Prolia, you should receive your injection as soon as you can.
Take good care of your teeth and gums