UVADEX(Methoxsalen) Sterile Solution 10 mL
Generic Name and Formulations:
Methoxsalen 20mcg/mL; sterile soln.
Company:
Therakos, Inc.
Indications for UVADEX:
Extracorporeal administration with the UVAR Photopheresis System in the palliative treatment of skin manifestations of cutaneous T-cell lymphoma that is unresponsive to other forms of treatment.
Adult:
Consult UVAR Photopheresis System Operator's Manual before administering. Give on two consecutive days every 4 weeks for minimum of 7 treatment cycles (6 months). 200mcg per photopheresis treatment. Accelerated treatment schedule: see literature.
Children:
Not recommended.
Contraindications:
Idiosyncratic reactions to psoralen compounds. History of light sensitive disease. Lupus erythematosus. Porphyria cutanea tarda. Erythropoietic protoporphyria. Variegate porphyria. Xeroderma pigmentosum. Albinism. Aphakia.
Warnings/Precautions:
Exposure to sun or UV light may cause actinic degeneration, skin burning, cataracts; wear UVA-absorbing, wrap-around sunglasses and cover exposed skin (or use sunblock: SPF ≥15) for 24hrs after treatment. Basal cell carcinomas (monitor and treat if occur). Pregnancy (Cat.D); nursing mothers: not recommended.
Interactions:
Increased photosensitivity with anthralin, coal tar, griseofulvin, phenothiazines, nalidixic acid, halogenated salicylanilides, sulfonamides, tetracyclines, thiazides, organic staining dyes.
Pharmacological Class:
Photoactive agent.
Adverse Reactions:
Hypotension secondary to changes in extracorporeal volume.
How Supplied:
Vials (10mL)—12