PLATO®-100 TABLETS
SCHEDULING STATUS:
S3
PROPRIETARY NAME
(and dosage form):
PLATO®-100 TABLETS
COMPOSITION:
Each tablet contains 100mg Dipyridamole.
PHARMACOLOGICAL CLASSIFICATION:
A 8 Drugs acting on blood and haemopoietic system.
PHARMACOLOGICAL ACTION:
Dipyridamole is readily absorbed from the gastro-intestinal tract. In single doses of 100mg it reduces platelet adhesiveness and aggregation. Platelets play a very important part in the formation of white thrombi, thromboses in arteries and initiation of the mechanisms of thrombosis. It reduces permeability of red cell membrane to adenosine. Intracellular interaction between adenosine and ATP is inhibited, thus less ADP is formed. As a result of this mechanism the ADP induced aggregation and adhesiveness is greatly reduced.
INDICATIONS:
All conditions where reduction in platelet aggregation and/or adhesiveness is considered to be of therapeutic benefit.
CONTRA-INDICATIONS:
Hypersensitivity.
Patients with hypotension following myocardial infarction.
DOSAGE AND DIRECTIONS FOR USE:
One tablet (100mg) four times a day before food, (usually one tablet three times a day and one at bedtime).
Aspirin potentiates the effect of dipyridamole and a reduction in dosage may be necessary. Dipyridamole can be combined with aspirin (1000mg per day) in divided doses.
SIDE-EFFECTS AND SPECIAL PRECAUTIONS:
Instances of headache, vertigo, nausea, vomiting, diarrhoea and flushing have been reported. Where possible, dosage should commence with one tablet in the morning and evening for 5days, one three times a day for 5days and then one four times a day. Dipyridamole should be given with care to patients with hypotension.
KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT:
See "Side-effects and Special Precautions". Treatment is symptomatic.
CONDITIONS OF REGISTRATION:
To be advertised to the professions only.
IDENTIFICATION:
Yellow sugar-coated tablets
PRESENTATION:
Sercuritainers containing 100 tablets.
STORAGE INSTRUCTIONS:
Store below 25°C. Protect from moisture.
KEEP OUT OF REACH OF CHILDREN.
REGISTRATION NUMBER:
K/8/297
NAME AND BUSINESS ADDRESS OF THE APPLICANT:
Pharmacare Limited
7 Fairclough Road
PORT ELIZABETH 6100
DATE OF PUBLICATION OF THIS PACKAGE INSERT:
06/06/79
G895
A & S PRINTERS
Updated on this site: May 2000 |
