MEDAZINET Tablets
SCHEDULING STATUS:
S2
PROPRIETARY NAME
(and dosage form)
MEDAZINET Tablets
COMPOSITION:
Each tablet contains 50mg
cyclizine hydrochloride.
PHARMACOLOGICAL CLASSIFICATION:
A 5.7.2. Anti-emetics and antivertigo preparations.
PHARMACOLOGICAL ACTION:
Cyclizine is an antihistamine with anti-emetic properties.
INDICATIONS:
Medazine T is indicated in the prevention and treatment of nausea and vomiting. It is indicated in prophylaxis and treatment of motion sickness, in the symptomatic management of vertigo and labyrinth disorders (Meniere's disease).
CONTRA-INDICATIONS:
Medazine T is contra-indicated in individuals who have previously reacted adversely to cyclizine. Medazine T is contra-indicated in pregnancy.
WARNINGS:
Medazine T tablets may lead to drowsiness and impaired concentration, which may be aggravated by simultaneous intake of alcohol or other central nervous system depressant agents. Patients should be warned against taking charge of vehicles or machinery or performing potentially hazardous tasks where loss of concentration may lead to accidents.
DOSAGE AND DIRECTIONS FOR USE:
|
Adults and children over 12years: |
1tablet three times a day |
|
Children 6to 12years: |
½a tablet three times a day |
For the prevention of motion sickness, one tablet is taken 20to 30minutes before departure. This dose may be repeated every 4to 6hours if necessary. The dosage for children aged 6to 12years is half the adult dosage.
SIDE-EFFECTS AND SPECIAL PRECAUTIONS:
The most common side-effect of
Medazine T is sedation which can vary from slight drowsiness to deep sleep, and including inability to concentrate, lassitude, dizziness, hypotension, muscular weakness and inco-ordination. Other side-effects include gastro-intestinal disturbances such as nausea, vomiting, diarrhoea or constipation and epigastric pain. Headache, tinnitus, elation or depression, irritability, nightmares, anorexia, difficulty in micturition, dryness of the mouth, tightness of the chest, and tingling, heaviness and weakness of the hands may occur.
Fixed drug eruptions, generalised chorea, and hypersensitivity hepatitis have been reported after oral administration.
In children it may act as a cerebral stimulant. Symptoms of stimulation in adults include insomnia, nervousness, tachycardia, tremors, muscle twitching and convulsions.
Large doses may precipitate fits in epileptics. Allergy and anaphylaxis may occur. Blood dyscras
