Generic Name and Formulations:
Linagliptin 5mg; tabs.

Company:
Boehringer Ingelheim and Lilly

Indications for TRADJENTA:
Adjunct to diet and exercise in type 2 diabetes mellitus, as monotherapy or combination therapy. Limitations of use: not for treatment of type 1 diabetes or diabetic ketoacidosis. Not studied in patients with a history of pancreatitis.

Adult Dose for TRADJENTA:
5mg once daily.

Children's Dose for TRADJENTA:
<18yrs: not established.

Pharmacological Class:
Dipeptidyl peptidase-4 inhibitor.

Warnings/Precautions:
Monitor for signs/symptoms of pancreatitis; discontinue if suspected. Pregnancy (Cat.B). Nursing mothers.

Interactions:
Antagonized by strong P-gp or CYP3A4 inducers (eg, rifampin); consider alternatives to linagliptin if used in combination. May need lower dose of concomitant sulfonylurea or insulin to reduce risk of hypoglycemia.

Adverse Reactions:
Nasopharyngitis, hypoglycemia, arthralgia, back pain, headache; hypersensitivity reactions (eg, urticaria, angioedema, localized skin exfoliation, bronchial hyperreactivity), myalgia, pancreatitis.

Metabolism:
Extensively unchanged.

Elimination:
Enterohepatic (80%), renal (5%).

Generic Availability:
NO

How Supplied:
Tabs—30, 90