Generic Name and Formulations:
Canagliflozin 100mg, 300mg; tablets.
Company:
Janssen Pharmaceuticals, Inc.
Indications for INVOKANA:
Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Limitations of use: not for treating type 1 diabetes or diabetic ketoacidosis.
Adult Dose for INVOKANA:
See full labeling. Take before first meal of the day. Initially 100mg once daily; if tolerated and with eGFR ≥60mL/min/1.73m2, and need additional glycemic control; may increase to 300mg once daily. Moderate renal impairment (eGFR 45–<60mL/min/1.73m2): 100mg once daily; if eGFR <45mL/min/1.73m2: do not initiate. Concomitant UGT inducers in patients with eGFR ≥60mL/min/1.73m2: consider increase to 300mg once daily; if eGFR 45–<60mL/min/1.73m2: consider other antihyperglycemics.
Children's Dose for INVOKANA:
<18yrs: not established.
Pharmacological Class:
Sodium-glucose co-transporter 2 (SGLT2) inhibitor.
Contraindications:
Severe renal impairment (eGFR <30mL/min/1.73m2), ESRD, or patients on dialysis.
Warnings/Precautions:
Correct volume depletion before starting therapy. Monitor for symptomatic hypotension in patients with renal impairment (eGFR <30mL/min/1.73m2), elderly, low systolic BP, concomitant diuretics or drugs that interfere with the renin-angiotensin-aldosterone system (eg, ACEIs, ARBs). Monitor renal function before and during therapy; more frequently if eGFR <60mL/min/1.73m2. Monitor K+ levels in patients with renal impairment and predisposed to hyperkalemia.Risk of genital mycotic infections; monitor and treat. Monitor LDL levels and treat per standard of care. Severe hepatic impairment: not recommended. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Interactions:
Antagonized by UGT inducers (eg, rifampin, phenytoin, phenobarbital, ritonavir): see Adults dose. Concomitant digoxin: monitor. Concomitant insulin or insulin secretagogue: consider a lower dose of insulin/insulin secretagogue to reduce risk of hypoglycemia.
Adverse Reactions:
Female genital mycotic infections, urinary tract infection, increased urination; hypersensitivity reactions (discontinue if occurs).
Generic Availability:
NO
How Supplied:
Tabs—30, 90, (10x10 blister cards), 500
