Generic Name and Formulations:
Donepezil HCl 5mg, 10mg, 23mg; tabs.

Company:
Eisai Pharmaceuticals

Indications for ARICEPT:
Alzheimer's dementia.

Adult Dose for ARICEPT:
Tabs: Swallow whole with water. ODT: dissolve on tongue, then drink water. Mild-moderate: Initially 5mg daily at bedtime, may increase to 10mg daily after 4–6 weeks; usual dose: 5mg or 10mg once daily. Moderate-severe: initially 10mg daily at bedtime, may increase to 23mg daily after 3 months; usual dose: 10mg or 23mg once daily.

Children's Dose for ARICEPT:
Not applicable.

See Also:
ARICEPT ODT

Pharmacological Class:
Reversible acetylcholinesterase inhibitor (piperidine deriv).

Warnings/Precautions:
Cardiac conduction conditions. Peptic ulcer. Monitor for GI bleeding. Seizures. Asthma or COPD. GI or GU obstruction. Body weight <55kg. Pregnancy (Cat.C). Nursing mothers.

Interactions:
Drugs that affect CYP2D6 and CYP3A4 may affect rate of elimination. Antagonizes anticholinergics. May potentiate succinylcholine-type muscle relaxants, other cholinesterase inhibitors, cholinergic agonists (eg, bethanecol). Concomitant NSAIDs may increase risk of GI bleed.

Adverse Reactions:
GI upset, insomnia, muscle cramps, fatigue, anorexia, weight loss (esp. using 23mg/day dose).

How Supplied:
Tabs 5mg, 10mg—30, 90, 1000; 23mg—30, 90; ODT—30