Generic Name and Formulations:
Formoterol (as fumarate) 20mcg/2mL; soln for inh.

Company:
Mylan Pharmaceuticals

Indications for PERFOROMIST:
Long-term maintenance treatment of COPD-associated bronchoconstriction.

Adult Dose for PERFOROMIST:
20micrograms (1 vial) by nebulizer twice daily (AM & PM). Use standard jet nebulizer (eg, PARI-LC Plus [with face-mask or mouthpiece]) and air compressor (eg, Proneb Ultra compressor). Does not need to be diluted before nebulization. Do not mix with other drugs.

Children's Dose for PERFOROMIST:
Not recommended.

Pharmacological Class:
Long-acting beta-2 agonist.

Contraindications:
In patients with asthma without use of a long-term asthma control medication.

Warnings/Precautions:
Increased risk of asthma-related death. Do not initiate in acutely deteriorating COPD. Not for the treatment of asthma. Not for relief of acute symptoms. Prescribe a short-acting, inhaled β2-agonist for acute symptoms; monitor for increased need. Not for use with other long-acting β2-agonists. Do not exceed recommended dose. Cardiovascular disease (esp. hypertension, coronary insufficiency, arrhythmias). Convulsive disorders. Thyrotoxicosis. Hyperresponsiveness to sympathomimetics. Diabetes. Ketoacidosis. Hypokalemia. Labor & delivery. Pregnancy (Cat.C). Nursing mothers.

Interactions:
Caution with MAOIs, tricyclics, others that prolong QTc interval (may cause ventricular arrhythmias). Antagonized by β-blockers. K+-depleting diuretics, xanthines, steroids may potentiate hypokalemia. Sympathetic effects potentiated by additional adrenergics (caution).

Adverse Reactions:
GI upset, nasopharyngitis, dry mouth, dizziness, insomnia; ECG changes or cardiovascular effects (eg, increased BP, tachycardia; consider discontinuing if occur); hypokalemia, hyperglycemia, metabolic acidosis; hypersensitivity reactions; rarely: paradoxical bronchospasm, increased risk of asthma-related death.

How Supplied:
Single-use vials (2mL)—60