Giapreza(Angiotensin II Injection for Infusion) 

GIAPREZA Rx

Indications for GIAPREZA:

 

To increase blood pressure in septic or other distributive shock.

 

Adult:

 

Give by IV infusion. Initially 20ng/kg/min. May titrate every 5mins by increments of up to 15ng/kg/min as needed based on BP response; max 80ng/kg/min during first 3hrs of treatment. Maintenance dose: max 40ng/kg/min. Doses as low as 1.25ng/kg/min may be used. Once sufficiently improved, down-titrate every 5–15mins by increments of up to 15ng/kg/min based on BP.

 

Children:

 

 Not established.

 

Warnings/Precautions:

 

Risk of thrombosis. Use concurrent VTE prophylaxis. Pregnancy. Nursing mothers.

 

Interactions:

 

Concomitant ACE inhibitors may increase response. Concomitant ARBs may decrease response. 

 

Pharmacological Class:

 

Vasoconstrictor.

 

Adverse Reactions:

 

Thromboembolic events (eg, deep vein thrombosis), thrombocytopenia, tachycardia, fungal infection, delirium, acidosis, hyperglycemia, peripheral ischemia.

 

Generic Availability:

 

NO

 

How Supplied:

 

Single-dose vial (1mL, 2mL)—1