Primaxin IM (Imipenem and Cilastatin)
PRIMAXIN IM 500 Rx
Generic Name and Formulations:
Imipenem 500mg, cilastatin sodium 500mg; IM inj; sodium content 2.8mEq/g imipenem.
Company:
Merck & Co., Inc.

Select therapeutic use: Bacterial infections
Indications for PRIMAXIN IM 500:
Susceptible mild to moderate infections including lower respiratory tract, intraabdominal, skin and skin structure, gynecologic. IM form not for severe or life-threatening infections.

Adult:
Base dose on imipenem component. Lower respiratory tract, skin and skin structure, gynecologic: mild to moderate: 500–750mg every 12 hours. Intraabdominal: 750mg every 12 hours. CrCl <20mL/min: not recommended.

Children:
Not recommended.

Contraindications:
IM: Allergy to amide-type local anesthetics. Heart block. Severe shock.

Warnings/Precautions:
Penicillin, cephalosporin, or other allergy. CNS disorders (esp. brain lesions or seizures). Renal impairment: reduce dose. Hemodialysis: see literature. GI disease (esp. colitis). IM: prepare with lidocaine (see literature). Pregnancy (Cat.C). Nursing mothers.

Interactions:
Concomitant ganciclovir (increased seizure risk), probenecid: not recommended. May antagonize valproic acid; monitor (consider alternative therapy).
Pharmacological Class:
Carbapenem (thienamycin) + dehydropeptidase I inhibitor.

Adverse Reactions:
Local reactions, GI upset, confusion, myoclonia, seizures, changes in serum electrolytes, dizziness, somnolence, anaphylaxis, blood dyscrasias, elevated liver enzymes, fever, rash, hypotension.

How Supplied:
Vials (IV)—25
Vials (IM)—10